Synthesis of quaternary ammonium salt modified nucleophilic NO donor

A synthesis method and quaternary ammonium modification technology, which is applied in the field of medical engineering, can solve the problems that nucleophilic NO donors cannot be directly targeted and cannot react in a homogeneous phase, so as to improve antithrombotic performance, stabilize chemical properties, and prevent recurrence. narrow effect
CN100494223CInactive Publication Date: 2009-06-03SHANGHAI JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI JIAOTONG UNIV
Publication Date
2009-06-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is synthesis of quaternary ammonium salt modified nucleophilic chitosan NO donor, and belongs to the field of medicine engineering technology. The synthesis includes the following steps: 1. reacting chitosan to quaternary aminate its NH2 radical and obtain ammonium salt modified chitosan molecule; and 2. reacting the ammonium salt modified chitosan molecule with NO gas molecule at high pressure in methanol solution of sodium methoxide to produce [N(O)NO] radical; washing the product with methanol and ether for several times, separating to purify, re-crystallizing, vacuum drying at room temperature and storing in a drier at -20 deg.c. The quaternary ammonium salt modified nucleophilic chitosan NO donor of the present invention has stable chemical property and relatively long release half life, and may be applied widely in treating cardiac vascular diseases and hypertensive lung, promoting wound healing, etc.
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Description

technical field

[0001] The invention relates to a method in the technical field of medical engineering, in particular to a method for synthesizing chitosan nucleophilic NO donor modified by quaternary ammonium salts. Background technique

[0002] As a natural polymer material containing biological information, chitosan and its derivatives have both biocompatibility and biodegradability, and can be decomposed by lysozyme in organisms. When used in related medical fields, their safety is relatively high. Other synthetic materials are more reliable. The potential of chitosan as a biomedical material stems from its cationic character and high charge density in solution. The derivatization reaction of chitosan provides a new way to enhance the bioactivity and improve the mechanical properties of materials. The hydroxyl and amino groups in chitosan molecules are easy to chemically modify, and then can be made into various types of membranes, gels, polyelectrolytes and other mate...

Claims

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