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Use of columbin, isocolumbin, deoxidized fibraurin in preparing antiphlogistic, stomach convulsion, stomach ache medicine

A technology of oxystigmata and bittern, which is applied in the field of medicine, can solve the problems of differences in cure rate and effective rate, no quality standards, and insufficient pharmacological screening, etc.

Inactive Publication Date: 2009-06-24
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with magnesium sulfate in the control group, the cure rate and effective rate were statistically different (P<0.01, P<0.05)
[0006] Although Jinguolan has such a good clinical application effect, due to the lack of in-depth research on its chemical components and insufficient pharmacological screening, the active ingredients are not clear and there is no feasible quality standard

Method used

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  • Use of columbin, isocolumbin, deoxidized fibraurin in preparing antiphlogistic, stomach convulsion, stomach ache medicine
  • Use of columbin, isocolumbin, deoxidized fibraurin in preparing antiphlogistic, stomach convulsion, stomach ache medicine
  • Use of columbin, isocolumbin, deoxidized fibraurin in preparing antiphlogistic, stomach convulsion, stomach ache medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] Extract 2.5kg of dried medicinal material of Lavenderia quinquefolium, extract twice with 50 liters of 95% solution, 2 hours each time, combine the two extracts, concentrate under reduced pressure to obtain 120g of extract, disperse with 2 liters of water, and extract three times with 6L chloroform Concentrate the extraction part under reduced pressure to obtain 20 g of the crude product, heat and dissolve the crude product with 500 ml of methanol, filter while it is hot, and refrigerate the filtrate in a refrigerator at 4°C overnight to separate out the combination of columbin, isocolumbin and deoxyaldopicrin The product crystallized, filtered through filter paper, and dried to obtain 12g of the composition. Take 10g of the composition, mix it with 50g of silica gel as a sample, add it to the top of the silica gel column that has been installed, and use petroleum ether:chloroform (20:1~5:1) system Gradient elution, TLC tracking, combined eluents containing the same comp...

Embodiment 2

[0134] Tablet: active ingredient (three monomers or combination) 17g

[0135] Lactose 200g

[0136] Cornstarch 50g

[0137] Magnesium Stearate 3g

[0138] Made into 1000 pieces

[0139] Preparation method: mix the active ingredient, lactose and starch, uniformly moisten with water to make a soft material, granulate the wetted mixture, pass through a 20-mesh sieve, dry at 80°C, add magnesium stearate, sieve again, and then The mixture is compressed into tablets, each tablet weighs 270 mg, and the active ingredient content is 17 mg.

[0140] The active ingredient of the present invention is combined with related carriers, and can also be made into other solid preparations, such as powders, granules, capsules and the like. The technology of these preparations is very mature, so I won't list them one by one here.

Embodiment 3

[0142] Infusion solution: active ingredient (three monomers or combination) 2g

[0143] Sodium chloride 9g

[0144] Water for injection 100000ml

[0145] Makes 1000 bottles

[0146] Preparation method: Dissolve the active ingredient and sodium chloride in 100,000ml of water for injection, add 0.01% activated carbon for adsorption, detect intermediates, filter through a 0.45um membrane, subpackage, 100ml / bottle, sterilize, and inspect.

[0147] The active ingredients of the present invention can be combined with related adjuvants to make other liquid preparations, such as nasal sprays, injections and the like.

[0148] The above-mentioned pharmaceutical dosage forms can be effectively used for the treatment and prevention of acute and chronic inflammation, stomach spasm, stomach disease and related diseases.

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Abstract

The invention discloses the use of isocolumbin, columbin and fibleucin in preparing medicament for the prevention and treatment of acute and chronic inflammation, stomach spasm and stomach ache, by using them as active ingredients, matched by pharmaceutically acceptable carrying agents, medicament can be prepared with the dosage forms of tablets, powders, granules, capsules, transfusions and injections.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the new medical application of columbin, isocolumbin and deoxylutein. Specifically, it relates to the application of columbine, isocolumbin and desoxypalatin in the preparation of medicines for preventing and treating acute and chronic inflammation, stomach spasm and stomach pain. Background technique [0002] Various inflammatory diseases are common and frequently-occurring diseases that endanger human health at present, involving a wide range of areas and causing great harm. Throughout the current treatment of acute and chronic inflammation, although antibiotics and hormone-based treatments can achieve good results, due to the continuous increase of drug-resistant strains, there are more and more cases. The condition is not controlled in time, and it is not uncommon for antibiotics to produce side effects in clinical application, some of which are caused by viral infections, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61K9/08A61K9/10A61K9/107A61K9/20A61K9/48A61P1/04A61P11/00A61P11/04A61P29/00
Inventor 张卫东史琪容张川苏娟柳润辉徐希科
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY