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Control of cardiac arrhythmias by modification of neuronal conduction within fat pads of the heart

A technology of arrhythmia and neurons, applied in medical science, bandages, etc., can solve problems such as the formation of thrombosis collagen and tissue structure damage

Inactive Publication Date: 2009-07-29
卡迪奥高分子材料公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

While significant advantages and successful therapeutic effects have been observed when creating conduction blocks using the various techniques described above, each approach has certain adverse consequences
For example, ablative hyperthermia or other necrosis-inducing modes have been observed to cause scarring, thrombus formation, collagen contraction, and detrimental structural damage to deeper tissues

Method used

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  • Control of cardiac arrhythmias by modification of neuronal conduction within fat pads of the heart
  • Control of cardiac arrhythmias by modification of neuronal conduction within fat pads of the heart
  • Control of cardiac arrhythmias by modification of neuronal conduction within fat pads of the heart

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experiment example

[0103]The surgical preparation was as follows: Two adult mongrel dogs (body weight 23 to 30 kg) were premedicated intravenously with sodium thiopental (20 mg / kg), intubated and ventilated (Narkomed type 2, obtained from NorthAmerican Drager, Telford, PA) administered room air supplemented with oxygen on demand to maintain normal arterial blood gases. Anesthesia was then maintained throughout the experiment with 1% to 2% isoflurane. Intravenous saline solution at a rate of 100 to 200 mL / hour is given to replace spontaneous fluid loss. Throughout the study, standard ECG leads (I, П, Ш) on the body surface were continuously monitored. Check arterial blood gases intermittently and adjust the ventilator to correct any metabolic abnormalities. Rectal temperature was monitored with a rectal probe, and the dog's body temperature was maintained at 36 to 37°C with a heating pad under the dog's body and an operating room light.

[0104] The right femoral artery was cannulated and a mi...

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Abstract

To control arrhythmias, various conduction modulators, including biopolymers, fibroblasts, neurotoxins, and growth factors, are introduced epicardially or endocardially into the vicinity of the ganglion in the fat pad. Injection may be performed using any desired technique, including may be from a catheter inserted percutaneously, or may be injected directly through the epicardium during open heart surgery. Preferably, the patient's heart beats throughout the injection.

Description

[0001] inventor [0002] Nicholas Peters, is a British citizen residing in London, England. [0003] Mark Maciejewski is a US citizen residing in Edina, Minnesota, USA. [0004] Cross-Referenced Related Applications [0005] This application claims priority to U.S. Provisional Patent Application No. 60 / 519,588, filed November 13, 2003 ("Method to Control Ventricular Rate" by Peters et al.), U.S. Provisional Patent Application, filed November 20, 2003 No. 60 / 523,848 ("Method to Cure Atrial Fibrillation by Modifying Local Autonomic Supply" by Peters et al.), U.S. Provisional Patent Application No. 60 / 550,185 filed March 3, 2004 ("Treatment of Cardiac Supply" by Peters et al. Arrhythmias"), and U.S. Provisional Patent Application No. 60 / 550,076, filed March 4, 2004 ("Treatment of Cardiac Arrhythmias with Neurotoxins" by Peters et al.), the entire contents of which are hereby incorporated by reference This article. technical field [0006] The present invention relates to the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F13/00
Inventor 马克·马切耶夫斯基尼古拉斯·S·皮特斯
Owner 卡迪奥高分子材料公司
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