Oil-in-water baicalin nano-milk oral liquid and its preparing process
An emulsion oral liquid, oil-in-water type technology, applied in the field of medicine, can solve the problems of low bioavailability, reduce the curative effect of baicalin, and low solubility, and achieve the effect of improving solubility, good solubilization, and improving solubility
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Embodiment 1
[0048]Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 1.4g of Tween-80, 0.7g of Span-80, and 0.9g of liquid paraffin, put them into a beaker, and mix them thoroughly by manual stirring at a room temperature of 20°C, then slowly add distilled water to it, and add distilled water at the same time While stirring manually, the viscosity of the system is small at the beginning. With the increase of distilled water, the system will become viscous. At this time, the system may appear liquid crystal state or water-in-oil nanoemulsion. Continue to add drops and stir constantly. When the system suddenly becomes When it is thin, what is produced at this time is the O / W type nanoemulsion. 0.01g baicalin is directly added, stirred until it is completely dissolved, and finally a stable yellow transparent oil-in-water type baicalin nanoem...
Embodiment 2
[0050] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 1.8g of Tween-80, 0.6g of Span-80, and 0.6g of liquid paraffin, put them into a beaker, and stir them by hand at room temperature of 24°C to mix them well, then slowly add distilled water to it, and add distilled water at the same time While stirring manually, the viscosity of the system is small at the beginning. With the increase of distilled water, the system will become viscous. At this time, the system may appear liquid crystal state or water-in-oil nanoemulsion. Continue to add drops and stir constantly. When the system suddenly becomes When it is thin, what is produced at this time is the O / W type nanoemulsion. Add 0.05g of baicalin directly, stir until it is completely dissolved, and finally obtain a stable yellow transparent oil-in-water type baicalin nanoemuls...
Embodiment 3
[0052] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 4.5g of polyoxyethylene hydrogenated castor oil and 0.5g of olive oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 22°C, then slowly add distilled water to it, and manually stir while adding distilled water, At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear in a liquid crystal state or a water-in-oil nanoemulsion. Continue to add drops and stir continuously. O / W type nanoemulsion is produced at the time, the baicalin of 0.10g is directly added, stirs until all dissolvings, what finally obtains is stable yellow transparent oil-in-water type baicalin nanoemulsion oral liquid, claims its weight as 10.15 g.
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