Sound wave needle inserting system for micro needle array plaster

Abstract

The invention discloses an acoustic wave needle insertion system for a microneedle array patch, which is characterized in that it includes a fixed ring and a sound wave vibration generator, and the lower part of the inner edge of the fixed ring is provided with a fixed ring sheet extending inward, and the sound wave vibrates The generator extends into the fixed ring, the lower end is positioned by the gasket and the fixed ring, and the bottom surface of the gasket is pasted with a positioning patch to form the installation position of the microneedle array patch; wherein, the working frequency of the acoustic vibration generator is 10HZ~ 100KHZ, the output power is less than 60W, and the position of the fixed ring piece is such that the distance from the adhesive patch to the bottom surface of the fixed ring is greater than the height of the corresponding microneedle array patch. The invention can reduce the discomfort near the pain point of the patient, keep the penetration depth consistent on various types of skin, and avoid the difference caused by different skins.

Description

technical field [0001] The invention relates to a device related to the transdermal drug delivery technology, in particular to a device for repeatedly piercing a microneedle array chip which enhances the permeability of the transdermal drug delivery into the skin stratum corneum. Background technique [0002] Most drugs are currently administered orally in the form of tablets, capsules, etc. However, due to drug degradation in the gastrointestinal tract and the first-pass effect in the liver, many orally administered drugs are largely or completely ineffective before reaching the site of action. Another common way of administration is injection, including subcutaneous injection and intravenous infusion, which enables the drug to penetrate biological barriers (such as skin, mucous membrane, and vascular barrier). Although this method is effective, the injection will bring additional pain to the patient, and it is easy to cause local skin damage and bleeding at the injection ...

AI Technical Summary

Problems solved by technology

The biggest disadvantage of inserting microneedles into the skin by hand is that each person uses different strengths, resulting in significant differences in the depth of insertion. Even for the same person, the depth of insertion is different due to the difference in the strength of each insertion.

The use of an automatic needle inserter is to insert the microneedle array into the skin instantly under a certain force, and has the following disadvantages: (1) Because the nature of the skin is different, the depth of insertion is different; (2) If you want to make the needle deeper , need to have a relatively large elasticity, there is discomfort near the wound

This needle introducer can improve the repeatability of needle insertion, but it cannot account for the variation caused by different skins

However, no matter whether it is a hand prick or an automatic needle inserter, a certain force is required to make the microneedle array penetrate the skin. Because the microneedle array of polymer materials and some metal materials is usually tough but not hard enough, it is difficult to penetrate the skin or easily bend

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