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A caffeine micro capsule and preparation method thereof

A technology of caffeine and microcapsules, which is applied in the direction of microcapsules, capsule delivery, active ingredients of heterocyclic compounds, etc., to achieve the effects of facilitating storage, delaying and prolonging the efficacy of medicines

Inactive Publication Date: 2009-10-28
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report of coating caffeine into microcapsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] At a constant temperature of 60°C, dissolve 0.2 parts of caffeine in 20 parts of gelatin aqueous solution with a mass content of 10%, then add 1 part of Tween-80, stir evenly to form a mixed solution, and then add the above mixed solution to 78.8 parts of soybean oil at a temperature of 60°C formed a water-in-oil emulsion, stirred at 60°C at 200 rpm for 4 hours, cooled to 35°C, and added dropwise a glutaraldehyde solution with a mass content of 10%, causing a phase Separation and coagulation, stirring for 60 minutes, then cooling down to room temperature, and stirring for 5 hours, the particle size of the formed caffeine microcapsules is in the range of 700-1000 microns.

[0015] Then, the above-mentioned microcapsules are filtered and dried to obtain the finished product.

Embodiment 2

[0017] At a constant temperature of 50°C, dissolve 0.5 parts of caffeine in 16.7 parts of gelatin aqueous solution with a mass content of 10%, then add 1.4 parts of Tween-80, stir evenly to form a mixed solution, and then add the above mixed solution to 81.4 parts of soybean oil at a temperature of 50°C formed a water-in-oil emulsion, stirred at 50°C at 200 rpm for 5 hours, cooled to 5°C, and added dropwise a glutaraldehyde solution with a mass content of 5%, causing phase separation Coagulate, stir for 30 minutes, then rise to room temperature, stir for 6 hours, and the particle size of the formed caffeine microcapsules is in the range of 150-300 microns.

[0018] Then, the above-mentioned microcapsules are filtered and dried to obtain the finished product.

Embodiment 3

[0020] At a constant temperature of 40°C, dissolve 0.75 parts of caffeine in 25 parts of gelatin aqueous solution with a mass content of 15%, then add 3 parts of Tween-80, stir evenly to form a mixed solution, and then add the above mixed solution to 71.25 parts of soybean oil at a temperature of 40°C form a water-in-oil emulsion, stir at 350 rpm at 40°C for 4 hours, cool to 15°C, and add a glutaraldehyde solution with a mass content of 25% dropwise to cause phase separation Coagulate, stir for 40 minutes, then rise to room temperature, stir for 5 hours, and form caffeine microcapsules with a particle size in the range of 200 to 300 microns.

[0021] Then, the above-mentioned microcapsules are filtered and dried to obtain the finished product.

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Abstract

A caffeine microcapsule and a preparation method thereof belong to the technical field of pharmaceutical microcapsule preparation. The gelatin is coated on the outside of the caffeine, and the caffeine microcapsule particle diameter is in the range of 20-1500 microns. Caffeine is coated in gelatin microcapsules by emulsion method; the process is: at 40-70°C, dissolve 0.2-0.75 parts of caffeine in 16.7-25 parts of gelatin aqueous solution, and then add 1-4.3 parts of Tween -80, stir evenly to form a mixed solution, then add the above mixed solution to 71.25-87.16 parts of soybean oil at a temperature of 40-70°C to form a water-in-oil emulsion, stir at this temperature for 2-5 hours, and cool to Add glutaraldehyde solution dropwise at 5-35°C to cause phase separation and coagulation, stir for 30-60 minutes, then raise or lower to room temperature, stir for 3-6 hours, and collect caffeine microcapsules. The advantage is that the caffeine is covered with gelatin, which delays and prolongs the drug effect of the caffeine, and at the same time prevents the caffeine from absorbing moisture and is beneficial to storage.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical microcapsules, and in particular provides a caffeine microcapsule and a preparation method thereof. Background technique [0002] Caffeine is a central stimulant drug that has a wide range of exciting effects on the central nervous system. A small dose can enhance the exciting process of the cerebral cortex and the cortical motor area, making people lively and active. Small amounts of caffeine are contained in our daily beverages such as tea, cocoa, and chocolate, and small amounts of caffeine are also contained in carbohydrate drinks such as cola and certain narcotics. It can accelerate the metabolism of the human body, keep the mind clear and sharp, and stimulate athletes to create better results. Caffeine also has a mild diuretic effect. Clinically, it is mainly used to accelerate the recovery process of anesthetics, rescue the poisoning of central inhibitory drugs and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/522
Inventor 王戈郝建鸿杨穆
Owner UNIV OF SCI & TECH BEIJING
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