A caffeine micro capsule and preparation method thereof

Abstract

A caffeine microcapsule and a preparation method thereof belong to the technical field of pharmaceutical microcapsule preparation. The gelatin is coated on the outside of the caffeine, and the caffeine microcapsule particle diameter is in the range of 20-1500 microns. Caffeine is coated in gelatin microcapsules by emulsion method; the process is: at 40-70°C, dissolve 0.2-0.75 parts of caffeine in 16.7-25 parts of gelatin aqueous solution, and then add 1-4.3 parts of Tween -80, stir evenly to form a mixed solution, then add the above mixed solution to 71.25-87.16 parts of soybean oil at a temperature of 40-70°C to form a water-in-oil emulsion, stir at this temperature for 2-5 hours, and cool to Add glutaraldehyde solution dropwise at 5-35°C to cause phase separation and coagulation, stir for 30-60 minutes, then raise or lower to room temperature, stir for 3-6 hours, and collect caffeine microcapsules. The advantage is that the caffeine is covered with gelatin, which delays and prolongs the drug effect of the caffeine, and at the same time prevents the caffeine from absorbing moisture and is beneficial to storage.

Description

technical field

[0001] The invention belongs to the technical field of preparation of pharmaceutical microcapsules, and in particular provides a caffeine microcapsule and a preparation method thereof. Background technique

[0002] Caffeine is a central stimulant drug that has a wide range of exciting effects on the central nervous system. A small dose can enhance the exciting process of the cerebral cortex and the cortical motor area, making people lively and active. Small amounts of caffeine are contained in our daily beverages such as tea, cocoa, and chocolate, and small amounts of caffeine are also contained in carbohydrate drinks such as cola and certain narcotics. It can accelerate the metabolism of the human body, keep the mind clear and sharp, and stimulate athletes to create better results. Caffeine also has a mild diuretic effect. Clinically, it is mainly used to accelerate the recovery process of anesthetics, rescue the poisoning of central inhibitory drugs and ...