Filling bracket perfusion type bioreactor for artificial liver

A bioreactor and artificial liver technology, applied in the field of biomedicine, can solve the problems of uneven cell inoculation, poor biocompatibility, affecting growth and metabolic functions, etc., to achieve continuity and success, and reduce ineffective perfusion , Reduce the effect of perfusion dead space
CN100556381CActive Publication Date: 2009-11-04ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2009-11-04

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Abstract

The invention belongs to the technical field of medical biology, and relates to a perfusion type bioreactor for filling a scaffold for an artificial liver. The appearance is a cylindrical container, the liquid inlets 1 and 2 are at the upper and lower ends of the cylindrical container; the outlets 3 and 4 are symmetrically distributed in the center of the side wall; the physical support 6 has 14 to 16 staggered partitions to place and support the liver cell biology The bracket 5 has a liquid flow buffer 7 in the middle of the bracket in the reactor, and a cell screen and a cell screen brush are arranged at the outlet. The upstream of the two inlets of the bioreactor is connected to the membrane oxygenator 14 , and the downstream of the two outlets is connected to the immunoadsorber 15 . Liver cell bioscaffolds are chitosan scaffolds or alginic acid / chitosan and modified alginic acid / galactosylated chitosan / heparin scaffolds, which have good biocompatibility and are more suitable for the growth and function of liver cells . The physical scaffold with a staggered structure is similar to each functional unit of the liver, effectively preventing the collapse of the liver cell biological scaffold.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and relates to a medical device, a core device for the treatment of a biological or hybrid biological artificial liver-a artificial liver filling stent perfusion bioreactor. Background technique

[0002] The bioartificial liver uses part or all of the bioactive cells of the liver cells to enter the bioreactor, and the blood or some components flow through the reactor. During this process, the bioactive cells absorb the toxic substances in the blood, Transformation and detoxification, on the other hand, synthesize a variety of biologically active substances and release them into the blood to achieve the purpose of removing toxic components in the blood. The bioreactor is the core device of the biological and hybrid artificial liver support system. It is the place where exogenous liver cells and the patient's blood or plasma exchange substances. As a reactor, it generally meets the following ba...

Claims

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