Form board stationary beta hair clip ring analog and use in bacteriophage exhibition
A technology of immobilizing templates and mimetics, which is applied in the direction of microbial libraries, peptide preparation methods, chemical libraries, etc., can solve problems such as separation of affinity ligands, and achieve the effect of promoting strong activity and promoting binding-activity research
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Embodiment 1
[0247] Example 1 (n=8) is shown in Table 1. Starting with the amino acid Cys, the peptide was synthesized, and the Cys was grafted onto the resin. The starting resin was Fmoc-Cys(Trt)-chlorotrityl resin (prepared as described above). Linear peptides were synthesized on solid supports according to Procedure 1 in the following order: Resin-Cys-P8-P7-P6-P5-P4-P3-P2-P1-Cys, followed by acylation, cleavage, deprotection as indicated , purification and cyclization. HPLC retention time (min) and mass determined using the above gradient: RT = 7.26 min, [M+H] + = 1281.3.
Embodiment 2
[0248] Example 2 (n=8) is shown in Table 1. Starting with the amino acid Lys, the peptide was synthesized, and Lys was grafted onto the resin. The starting resin was Fmoc-Lys(Boc)-chlorotrityl resin (prepared as above). Synthesize linear peptides on a solid support according to Procedure 1 in the following order: Resin-R2 -Cys-P8-P7-P6-P5-P4-P3-P2-P1-Cys-R 1 , followed by acylation, cleavage, deprotection, purification and cyclization of the peptide as indicated. HPLC retention time (min) and mass determined using the above gradient: RT = 6.41 min, [M+H] + = 871.4.
Embodiment 3
[0249] Example 3 (n=10) is shown in Table 2. Starting with the amino acid Cys, the peptide was synthesized, and the Cys was grafted onto the resin. The starting resin was Fmoc-Cys(Trt)-chlorotrityl resin (prepared as above). Synthesize linear peptides on a solid support according to Procedure 1 in the following order: Resin-Cys-P10-P9-P8-P7-P6-P5-P4-P3-P2-P1-Cys, and then acylate the peptides as indicated. Synthesis, fragmentation, deprotection, purification and cyclization. HPLC retention time (min) and mass determined using the above gradient: RT = 5.74 min, [M+H] + = 779.2.
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