HIV-Env gene DNA allosterism recombination envelope protein antigen for immunoresponsiveness of anti-HIV test and method
An envelope protein, antigen immunization technology, applied in the field of life sciences, can solve problems such as cannot be reviewed one by one, cannot effectively prevent HIV infection, etc.
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[0009] In order to achieve the above object, implement the scheme that the present invention adopts:
[0010] HIV-Env gene DNA Allosteric Recombinant Envelope Protein Antigen Immune Response Anti-HIV Experiment and Method
[0011] 1. Experimental animals and human clinical trials
[0012] 1.1. Experimental animals: 4-6 weeks old germ-free animals, CBA / Ca mice, C57BL / 6 mice or BALB / c mice, Hu-PBL-SCID mice; non-human primates, Rhesus Monkey, gorilla.
[0013] 1.2. Human body for clinical trials: normal healthy people not infected with HIV-I, patients infected with HIV-I in the acute stage.
[0014] 2. Experimental Biomaterials
[0015] 2.1. Rat anti-mouse CD4 receptor monoclonal antibody IgC2a / b - heterogeneous specific ligand antigen of mouse CD4 receptor, simulate HIV-Env gene DNA recombinant envelope protein gp120 or gp160 - human CD4 receptor Rat anti-human or anti-rabbit and other animal monoclonal antibody IgC2a / b - a heterologous antigen that cannot bind to the mous...
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