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Human milk fortifiers and methods for their production

A technology of human milk fortifier and fortifier, which is applied in the field of human milk fortifier and can solve the problem of not being able to provide enough

Inactive Publication Date: 2007-08-08
MEDELA HLDG AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been found that mature donor milk does not provide adequate amounts of some nutrients to meet the rapid growth needs of low birth weight infants

Method used

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  • Human milk fortifiers and methods for their production
  • Human milk fortifiers and methods for their production
  • Human milk fortifiers and methods for their production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A liquid sample (100ml) of the human milk sample was collected. Human milk was collected from mothers of preterm infants or from human milk donors at >10 and <90 days postpartum, respectively. Milk samples were collected from milk expressed from the udder over the course of a day. The basic composition of this milk can be summarized as follows: 3.8% fat, 0.8% protein and 5.2% carbohydrates. Determine the actual energy content of the milk samples. The non-aqueous part of the milk (cream fat) was separated from the water part by centrifugation (10000rpm, 4°C) and the top layer (cream fat) was carefully removed and a known volume was added to 140ml of the mother's own milk to increase the energy in her milk levels up to the recommended levels for premature infants of a specific weight and age.

[0053] In addition, pasteurization and standard hospital-grade bacterial testing can be performed as standard operations.

[0054] Premature babies can be observed to grow and ...

Embodiment 2

[0056] A liquid sample (150ml) of the human milk sample was collected. Human milk was collected from mothers of infants with special needs (premature infants or sick full-term infants) or from human milk donors at >10 days and <90 days postpartum, respectively. Milk samples were collected from milk expressed from the udder over the course of a day. The basic composition of this milk can be summarized as follows: 3.8% fat, 0.8% protein and 5.2% carbohydrates. Determining the concentration of protein in milk samples. The non-aqueous part (cream) of the milk was separated from the water part by centrifugation (10000 rpm, 4°C) and the top layer (cream) was carefully removed. The aqueous layer was then concentrated by passing it through a filter impermeable to milk protein (30Kd Omega ultrafiltration tangential flow membrane, Pall; temperature as cold as possible, 19°C in specific cases). After the water fraction has been concentrated 5 times (pass the liquid through the filter ...

Embodiment 3

[0060] A liquid sample (500ml) of the human milk sample was collected. Human milk was collected from human milk donors who were more than 90 days postpartum. Milk samples were taken from milk expressed from the udder over the course of several days and stored frozen. The basic composition of this milk can be summarized as follows: 3.8% fat, 0.8% protein and 5.2% carbohydrates. Determination of protein concentration in milk samples. The non-aqueous part (cream) of the milk was separated from the water part by centrifugation (10000 rpm, 4°C) and the top layer (cream) was carefully removed. The aqueous layer was then concentrated by passing it through a filter impermeable to milk proteins (30Kd Omega ultrafiltration tangential flow membrane, Pall; temperature as cold as possible, in particular cases 19°C). After the aqueous fraction was concentrated 5-fold (as described in Example 2), the concentrated solution was centrifuged at high speed (210000 rpm, 4°C) to pellet the casei...

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Abstract

The present invention relates to a human milk fortifier as well as to several uses and a method for the production of such a fortifier. A particularly beneficial fortifier can be realised in that at least one human component based on a product directly or indirectly derived from human mammary secretion during non-pregnant, pregnant, lactating and / or involuting periods is used, giving rise to an optimally adapted fortifying effect which is particularly useful in the context of feeding preterm infants.

Description

technical field [0001] The present invention relates to human milk fortifiers. It also relates to specific methods of use of these fortifiers and methods of production of these fortifiers. technical background [0002] Human milk is generally considered the best food for infants due to its nutritional composition and immunological advantages. In addition, mature donor human milk is considered an ideal food for preterm, low birth weight infants in early neonatal intensive care units. However, it has been found that mature donor milk does not provide sufficient quantities of some nutrients to meet the rapid growth needs of low birth weight infants. For these reasons, premature infants' own mother's milk has become the food of choice in the modern neonatal intensive care unit. [0003] But not only premature, low-birth-weight infants, mature donor milk does not always supply the right mix of nutrients and immune components, and full-term infants at certain stages of developm...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23C9/20A61K35/20A23L33/00
Inventor 彼得·埃德温·哈特曼赖清塔吉利安·洛伊丝·谢里夫卡伦·诺里·西默尔米歇尔·安妮·刘易斯利昂·罗伯特·米图拉斯布龙文·埃斯特勒·达维斯
Owner MEDELA HLDG AG
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