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Bio-chip lattice method and device thereof

A biochip and dot matrix technology, applied in biological testing, microstructure devices, chemical instruments and methods, etc., can solve problems such as limited spacing

Inactive Publication Date: 2012-01-25
DR CHIP BIOTECH INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the reagent dipping needles on the spotter are still limited by the distance between the reagent storage equipment. If a 96-well disc is used as the reagent storage device of the aforementioned device as an example, the center-to-center distance between any two sample wells of the 96-well disc is generally 9 mm, if the diameter of the surface of the dipping needle of the device is 0.5 mm, and the configuration of the pointing needle also needs to match the distance between the two holes of the 96-well plate, to achieve a high-density microarray chip with the shortest distance between the centers of the two points of 1 mm, it must It takes up to 8 dipping actions to complete

Method used

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  • Bio-chip lattice method and device thereof
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  • Bio-chip lattice method and device thereof

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Embodiment Construction

[0060] Generally speaking, when the distance between reagent dipping needles is reduced, although the density of reagents on the surface of the microarray chip can be increased, it is difficult to fill the reagents and easily cause contamination. Therefore, the present invention provides a reagent plate that is easy to fill with reagents and can effectively reduce the distance between reagent spotting needles.

[0061] see figure 2 , which is a schematic diagram of the structure of the reagent tray of the present invention. The reagent tray 20 is composed of an upper tray 21 and a lower tray 22, which can be bonded by thermocompression bonding technology, screen printing adhesion technology, and double-sided adhesive tape. Technology and other methods to be bonded. The upper layer and the lower layer of the reagent disk of the present invention may be made of the same or different materials. Materials that can be used for the reagent disc of the present invention include bu...

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Abstract

This invention provides a method to increase the reticular density of the biochip including injecting different reagents into the holes, setting a slide glass on a glass basis, a unit of reagents dots, touching the reagent separately with the touching-hole, moving the unit of reagents dots to the touching point of the top of the slide glass basis and putting the reagents dots to the surface of the slide glass.

Description

technical field [0001] The invention relates to a biochip dot matrix method and its device, in particular to a dot matrix method and its device capable of increasing the density of the biochip. Background technique [0002] In the basic research or clinical diagnosis of modern medicine, molecular biological detection technology plays an increasingly important role, especially with the advancement of science and technology, microarray biochips that can perform a large number of detection and analysis at the same time have gradually become an emerging technology. important research tool. [0003] Generally speaking, the manufacturing methods of microarray biochips can be roughly divided into in-situ synthesis method, contact point ink method and non-contact inkjet method. The required equipment is semiconductor process equipment, microarray chip dot matrix Machines and micro-spray equipment, these processes or equipment require complex automatic control systems, and the cost ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N35/00G01N33/48B01J19/00B81C3/00G01N35/10
Inventor 陈建安林圣凯曾士原
Owner DR CHIP BIOTECH INC