Methods of device-assisted drug delivery

Abstract

This invention describes the simultaneous or sequential administration of therapeutic or diagnostic agents using different devices in combination with a chemical formulation that incorporates or uses vasomodulatory chemical agents as part of the drug delivery vehicle. Methods include the addition of various vasodilatory and vasoconstrictive agents to enhance the systemic or localized tissue delivery of therapeutic or diagnostic agents delivered into a body through the use of an apparatus or device.

Description

field of invention

[0001] The present invention relates to transdermal administration of therapeutic or diagnostic substances with devices or devices to assist in the delivery process, including iontophoresis, sonophoresis, syringes and injection needles, and microneedle devices. The present invention specifically describes the enhanced drug delivery properties when these agents are formulated with vasomodulating chemicals to induce a vasodilation or vasoconstriction response in the tissue area subjected to the drug, such as the injection site. Background of the invention

[0002] Systemic or topical delivery of drugs has been performed for many years by dermal administration using syringes and needles. However, the physical action of the needle penetrating the skin has certain significant negative reactions, including pain and discomfort, and potential adverse reactions to local tissues due to the trauma of physical disruption caused by relatively large needles penetrating ...