Optically enhanced chiral ionic liquids
A technology for ionic liquids and optical isomers, applied in the field of n.200-01 and methods, which can solve problems such as asymmetric results
Inactive Publication Date: 2007-09-12
SIGMA ALDRICH CO LLC
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Problems solved by technology
The result is asymmetrical
Method used
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Embodiment 1
[0172] When N,N-dimethylephedrine NTf2 was used as a cosolvent, the reaction gave about 3% enantiomeric excess (e.e). The reaction was carried out by NaBH at room temperature 4 Reduction of methyl phenyl ketones. Pass GC, use 20m Chiraldex TM G-PN column analysis of the reaction mixture.
[0173]
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Abstract
The invention relates to the use of optically enhanced chiral ionic liquids, particularly for gas chromatography and as a reaction solvent. Specific optically enhanced chiral cationic liquids are described as is a class of optically enhanced chiral anionic liquids.
Description
[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application No. 60 / 586,782, filed July 9, 2004, the contents of which are hereby incorporated by reference. Background of the invention [0003] Achiral ionic liquids have been used as solvents in the past. Racemic chiral liquids are also used as solvents. See Yasuhiro Ishida et al., "Design and synthesis of a novel imidazolium-basedionic liquid with planar chirality," Chem. Commun. 2240-41 (2002) (Copyright by the Royal Society of Chemistry). Solvents for enantiomerically increased chiral cations are also described. See Wasserscheid et al., "Synthesis and properties of ionic liquids derived from the 'chiral pool'," Chem. Commun. 200-01 (2002) and Weiliang Bao et al., "Synthesis of Chiral Ionic Liquids from Natural Amino Acids," 68 J.Org . Chem. 591 (2003). These solvents are not described as a medium for carrying out the subsequent reactio...
Claims
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IPC IPC(8): A61K31/18C07C307/02
CPCC07C67/333C07C311/48C07B2200/07C07D213/18C07C231/20C07C2101/14C07C2101/02C07C2103/90C07C309/65C07C29/143C07C2601/02C07C2601/14C07C2603/90C07C69/753C07C233/18C07C33/22C07C35/08C07C35/21C07C33/34
Inventor D·W·阿姆斯特朗J·丁
Owner SIGMA ALDRICH CO LLC
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