Microgel with nanometer grade sensitivity of temperature and PH value and preparation method thereof

A microgel and sensitive technology, which is applied in the field of nanoscale microgel with temperature and pH sensitivity and its preparation, can solve the problems of increasing total cost and time, and large particle size of colloidal particles, and achieve total saving The effect of cost and time, wide application range and simple process

Inactive Publication Date: 2007-09-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the particle size reaches the nanometer level, an emulsifier must be used, and the emulsifier must be removed in the post-

Method used

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  • Microgel with nanometer grade sensitivity of temperature and PH value and preparation method thereof
  • Microgel with nanometer grade sensitivity of temperature and PH value and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Put 1.5g of isopropylacrylamide, 0.05g of acrylic acid, and 0.1g of methylenebisacrylamide into 50g of deionized water at the same time, and stir to form a uniform and transparent reactant aqueous solution. The process conditions: the stirring speed is 300 rev / min, the time is 30 minutes.

[0047] The ammonium persulfate initiator of 0.1g is added into 50g deionized water, and at room temperature, it is made into an initiator aqueous solution with a concentration of 0.2% by weight, and first adjusted to pH=3 ± 0.5 with acetic acid, and then feeds nitrogen gas, and the stirring speed is 200 rev / min, gradually raise the temperature to 75°C, equilibrate for 30 minutes before use.

[0048] Under nitrogen conditions, the prepared 51.65g reactant aqueous solution was added dropwise in the aforementioned initiator aqueous solution, and the system changed from transparent to light blue after 10 minutes of reaction, and finally a milky white nano-scale microgel dispersion was ob...

Embodiment 2

[0053] Put 1.4g of isopropylacrylamide, 0.4g of acrylic acid, and 0.1g of methylenebisacrylamide into 50g of deionized water at the same time, and stir to form a uniform and transparent aqueous solution of reactants. The process conditions: the stirring speed is 300 rev / min, the time is 30 minutes.

[0054] Add 0.1 g of potassium persulfate initiator into 50 g of deionized water, and make an aqueous initiator solution with a concentration of 0.2% by weight at room temperature, adjust the pH to 3 ± 0.5 with acetic acid, and then pass in N 2 , the stirring speed is 200 rev / min, the temperature is gradually raised to 70°C, and it is ready to use after equilibrating for 30 minutes.

[0055] Under nitrogen conditions, the prepared 51.9g reactant aqueous solution was added dropwise in the aforementioned initiator aqueous solution, and the system changed from transparent to light blue after 10 minutes of reaction, and finally a milky white nano-scale microgel dispersion was obtained....

Embodiment 3

[0060] Dissolve 1.4g of vinyl acrylamide, 0.2g of acrylic acid, and 0.1g of methylenebisacrylamide in 50g of deionized water at the same time, and make a uniform and transparent reactant aqueous solution after stirring. The process conditions: the stirring speed is 300 rpm / minute, the time is 40 minutes.

[0061] Add 0.1 g of ammonium persulfate initiator to 50 g of deionized water, and make an aqueous initiator solution with a concentration of 0.2% by weight at room temperature, first adjust the pH to 3 ± 0.5 with acetic acid, and then pass in N 2 , the stirring speed is 200 rev / min, the temperature is gradually raised to 75°C, and it is ready to use after equilibrating for 30 minutes.

[0062] Under the nitrogen condition, the prepared 51.7g reactant aqueous solution was added dropwise in the aforementioned initiator aqueous solution, and the system changed from transparent to light blue after 10 minutes from the start of the reaction, and finally a milky white nano-scale ...

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Abstract

The invention relates to a temperature and pH valve sensitive nano microgel and a preparation method thereof. Structure formula of the microgel and copolymer thereof is shown above, wherein temperature sensitive monomer M is amide group containing compound, pH sensitive monomer N is carboxyl group containing compound, crosslinking agent O is acryloyl group containing compound, and mole ratio of amount of the three groups is 50-90 to 40-5 to 10-5. Degree of polymerization Z is 10-500. The method of preparing the microgel under condition of adding no emulsifier includes: employing specific dropping technique and nonsoap emulsion polymerization method, composing reactant water solution by M, N, O and water solvent according proportion, timed adding the reactant water solution to initiator water solution drop by drop, after ruleless copolymerizing and purifying, obtaining the double sensitive nano microgel with equal particle diameter of 40-300 nm and high stability. The microgel is easy to store, convenient for use and widely be used for medicament carrier and coating field. Advantages of the preparing method are: range of applicability is wide, technique is simple, and preparation can be large-scale production.

Description

technical field [0001] The invention relates to a microgel and a preparation method thereof in the field of polymer materials, in particular to a temperature- and pH-sensitive nanoscale microgel and a preparation method thereof. The obtained microgels are mainly used in the fields of drug carriers, chemical separation and biosensors. Background technique [0002] Gel is a solid-like and liquid-like substance composed of a liquid and a polymer network that is self-sustaining and stable, connected by Van der Waals force, hydrogen bond force and chemical bond force, and has a three-dimensional network structure. According to the liquid contained in the polymer network, it can be divided into hydrogel and organic gel. Hydrogel is a hydrophilic polymer between liquid and solid that can significantly swell in water and retain a large amount of water but is insoluble in water. It can be regarded as a hydrophilic network of water-soluble or hydrophilic polymers , can accommodate w...

Claims

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Application Information

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IPC IPC(8): C08F220/56C08F220/04C08F2/10C08F2/22C08F2/44C08F4/40C08F4/04A61K47/32
Inventor 张青松查刘生马敬红梁伯润
Owner DONGHUA UNIV
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