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Method for extracting effective portion, and new application for anti AIDS

A technology of anti-AIDS and effective parts, applied in medical preparations containing active ingredients, antiviral agents, pharmaceutical formulas, etc.

Inactive Publication Date: 2010-05-19
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, there is no relevant report on anti-AIDS of walnut and its effective parts

Method used

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  • Method for extracting effective portion, and new application for anti AIDS
  • Method for extracting effective portion, and new application for anti AIDS
  • Method for extracting effective portion, and new application for anti AIDS

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1: Preparation 1 of walnut aqueous extract

[0068] Weigh 5 kg of native medicinal walnut flakes or powder, add 5 times the amount of water, soak in water for 24 hours at 28°C, then use the percolation method to percolate until colorless, rotate and recover the percolation liquid, and obtain the walnut water extract Dry Powder A (479.93 g).

Embodiment 2

[0069] Embodiment 2: the preparation 2 of walnut aqueous extract

[0070] Weigh 5 kg of native medicinal walnut flakes or powder, add 5 times the amount of water, decoct under vacuum at 55°C for 3 times, each time for 3 hours, filter, combine the filtrates for 3 times, concentrate and dry into water extract dry powder B (479.93 g), dry and store for future use.

Embodiment 3

[0071] Embodiment 3: Preparation of effective parts of walnut

[0072] Take 8 grams of walnut aqueous extract dry powder A, add 10ml of water to dissolve, then apply macroporous adsorption resin HPD-450 for column chromatography, and elute with water, 30% ethanol, 50% ethanol, 75% ethanol and 95% ethanol respectively , the eluent was recovered and dried by rotation, and 5 kinds of powders of AA (4.32g), AB (1.76g), AC (0.88g), AD (0.096g) and AE (0.072g) were obtained respectively, among which AB and AE were effective parts.

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Abstract

A process for extracting the active components from walnut includes such steps as providing sliced or powdered walnut kernel, immersing in water, percolating, centrifugal recovery of percolated liquidto obtain dried extract A, dissolving in water, chromatography by macroreticular resin HPO-450, eluting respectively with water, 30% alcohol, 50% alcohol, 75% alcohol and 95% alcohol to obtain 5 kinds of powder AA, AB, AC, AD and AE, and taking AB and AE as active components. Said active components can be used to prepare anti-AIDS medicines.

Description

technical field [0001] The invention relates to a method for extracting effective parts of walnut and a new medical application for anti-AIDS. Background technique [0002] AIDS (AIDS) full name is acquired immunodeficiency syndrome (acquired immunodeficiency syndrome). The pathogen is HIV (human immunodeficiency virus, HIV), the human immunodeficiency virus. The outer layer of the HIV virion is made of fat, known as the viral envelope. There are 72 small lily-like suckers distributed on the surface of each viral outer membrane, and the flowers are scattered on the outer membrane facing outward. [0003] The bulk of the sucker is the gp120 adhesion protein, which is responsible for attaching the virus to the host cell surface. The handle of the sucker is a gp41 fusion protein, which is responsible for fusion and perforation of the host cell membrane. After the virus enters the human body, once it encounters cells with CD4, CXCR4 and CCR5 molecules on the surface, the suc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/52A61P31/18A61K135/00A61K133/00A61K131/00A61K127/00A61K125/00
Inventor 温瑞兴李泽琳刘兆梅闫红杨怡姝王小利马洪涛曾毅
Owner BEIJING UNIV OF TECH