Method for preparation of collagen / chitose supporting stand of composite hydroxylapatite

Abstract

The present invention discloses preparation process of collagen / chitosan rack with compounded hydroxyapatite. The preparation process includes the steps of: preparing cross-linked collagen / chitosan rack, chemical depositing to compound hydroxyapatite onto the rack, and mineralizing to obtain active compound bone rack. The preparation process is simple and has abundant material source and high production efficiency. The collagen / chitosan rack in bone-like structure has introduced active hydroxyapatite, and possesses the advantages of high biocompatibility, excellent comprehensive performance, use convenience and other advantages. The collagen / chitosan rack with compounded hydroxyapatite can promote the migration, growth and differentiation of bone cell, is favorable to raising the efficiency of repairing damaged bone tissue, and possesses excellent application foreground.

Description

technical field

[0001] The invention relates to a preparation method of a collagen / chitosan scaffold compounded with hydroxyapatite. Specifically, through the bionic simulation of human bone structure and function, collagen / chitosan and hydroxyapatite are used to simulate the extracellular matrix of bone cells, providing a method for preparing composite structural scaffolds for bone repair. Background technique

[0002] Bone injury is a common disease nowadays. Many patients suffer from articular bone injuries caused by various bone and joint diseases such as rheumatism and rheumatoid or sports trauma. So far, clinically, there is still a lack of effective methods for repairing large-sized bone defects. Applying the methods and principles of regenerative medicine to repair bone tissue is an important means at present, and has achieved good results. Among them, bone repair scaffolds play a very important role in bone regeneration.

[0003] Bone is a general term for a gro...

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