Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent

A tolyldiiodomethyl sulfone, dispersion technology for use in dandruff, compositions for the treatment of bacterial and fungal infections on the skin or scalp, in the field of topical fungal mediated conditions

Inactive Publication Date: 2008-01-23
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above-mentioned excellent effects are difficult to achieve

Method used

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  • Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent
  • Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent
  • Diiodomethyl-p-tolylsulfone as a particulate dispersion in a liquid solvent

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preparation example Construction

[0230] L. Methods of making shampoo compositions

[0231] The compositions of the present invention can be prepared by any known or otherwise effective technique suitable for providing antimicrobial compositions, provided that the resulting compositions provide the superior antimicrobial benefits described herein. Methods for preparing the anti-dandruff and conditioning shampoo embodiments of the present invention include conventional formulation and mixing techniques. Methods such as those described in US Pat. No. 5,837,661 can be used, wherein the antimicrobial, fungicide or anti-dandruff actives of the present invention typically can be combined with a silicone premix in the same step as described in US Pat. No. 5,837,661 join in.

preparation Embodiment 1 to 22

[0233] The following is a suitable method for preparing the antimicrobial shampoo compositions of Examples 1 to 22 (below):

[0234] About one-third to all of the sodium laureth sulfate (added as a 29% by weight solution) and acid are added to a jacketed mixing tank and heated to about 60°C to about 80°C with slow stirring. °C to form a surfactant solution. The pH of this solution is from about 3 to about 7. Sodium benzoate, cocamide MEA and fatty alcohol (if applicable) were added to the tank and allowed to disperse. Ethylene glycol distearate ("EGDS") was added to the mixing vessel and allowed to melt (if applicable). After the EGDS was melted and dispersed, Kathon CG was added to the surfactant solution. The resulting mixture was cooled to about 25°C to about 40°C and collected in a final tank. As a result of this cooling step, the EGDS crystallizes to form a crystalline network (if applicable) in the product. The remaining sodium laureth sulfate and other ingredients,...

preparation Embodiment 23 to 31

[0314] The following is a suitable method for preparing the antimicrobial cleaning compositions in Examples 23 to 31 (below):

[0315] Mix components 1 through 3, 6 and 7 while heating to 88°C (190°F). In a separate tank, components 4, 9, 12 and 14 were mixed at room temperature. After the first mixture had reached 88°C (190°F), it was added to the second mixture. After the mixture had cooled below 60°C (140°F), component 10 was added. In a separate vessel, combine petrolatum and diiodomethyl-p-tolylsulfone at 71°C (160°F). After the aqueous phase has cooled below 43°C (110°F), add the petrolatum / diiodomethyl-p-tolylsulfone and stir until homogeneous. With or without the aid of a dispersant, diiodomethyl-p-tolylsulfone can be added to the surfactant premix or to water, by conventional powder incorporation and mixing techniques, into the cooled mixture. Add the spices last.

[0316]

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Abstract

The present invention relates to compositions comprising an effective amount of diiodomethyl-p-tolylsulfone, wherein diiodomethyl-p-tolylsulfone is present as a dispersion of particles in a liquid solvent. In another embodiment, the present invention is directed to a composition wherein a retained activity of at least about 30% is obtained when said diiodomethyl-p-tolylsulfone is present as a dispersion of particles in a liquid solvent. In another embodiment, the present invention also relates to a composition wherein greater than 70% of said diiodomethyl-p-tolylsulfone remains in the liquid solvent in the form of a particle dispersion.

Description

field of invention [0001] The present invention relates to a composition comprising an effective amount of diiodomethyl-p-tolylsulfone, wherein diiodomethyl-p-tolylsulfone is present as a dispersion of particles in a liquid solvent. More particularly, the present invention relates to compositions and methods for treating bacterial and fungal infections on the skin or scalp. More specifically, the present invention relates to methods of treating topical fungal-mediated conditions, especially dandruff. Background of the invention [0002] Numerous anti-dandruff compositions are commercially available or otherwise known in the field of shampoos. These compositions typically contain a detersive surfactant and a particulate crystalline antimicrobial agent dispersed and suspended throughout the composition. Antimicrobial agents used for this purpose include sulfur, selenium sulfide, and polyvalent metal salts of pyrithione. During shampooing, these antimicrobial agents are depo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/46A61K8/27A61Q5/00A61K8/49
CPCA61Q19/00A61Q17/005A61Q5/02A61Q15/00A61K8/46A61K8/044A61Q5/00A61Q5/12A61Q5/006A61P31/00A61P31/10
Inventor 詹姆斯·R·施瓦茨戴维·T·沃恩克戴维·J·考夫曼
Owner THE PROCTER & GAMBLE COMPANY
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