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Tramadol hydrochloride and paracetamol combined injection

A technology of acetaminophen and tramadol hydrochloride, which is applied in drug combinations, anti-inflammatory agents, non-central analgesics, etc., and can solve the problems of low technological content and low added value

Inactive Publication Date: 2008-03-26
陈旭良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main products are paracetamol, aspirin and analgin, and the technology content of the products is not high, and the added value is very low. Compared with large foreign companies, my country's antipyretic and analgesic drugs are still in many aspects such as research and development innovation ability and technological level. hard to compete with

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 The preparation of 1000 3ml injections of the product of the present invention:

[0019] Tramadol Hydrochloride 37.5g

[0020] Acetaminophen 325g

[0021] Appropriate amount of pharmaceutical excipients

[0022] Water for injection 3000ml

[0023]

[0024] Makes 1000 bottles

[0025] Preparation:

[0026] 1. Accurately weigh tramadol hydrochloride and acetaminophen raw materials according to the above prescription ratio.

[0027] 2. Put tramadol hydrochloride into 600ml of water for injection heated to about 60°C, stir until completely dissolved, adjust the pH value to 4.5-6.5, and obtain liquid A for use.

[0028] 3. Put acetaminophen into 1500ml of water for injection, stir until it is completely dissolved, adjust the pH value to 4.5-6.5, and obtain liquid B for later use.

[0029] 4. Mix liquid A and liquid B evenly, and add water to the full volume of 3000ml.

[0030] 5. Add 0.03% activated carbon for i...

Embodiment 2

[0031] Embodiment 2 Preparation of product freeze-dried powder injection of the present invention:

[0032] Tramadol Hydrochloride 75g

[0033] Acetaminophen 650g

[0034] Appropriate amount of pharmaceutical excipients

[0035] Water for injection 5000ml

[0036]

[0037] Makes 1000 bottles

[0038] Preparation:

[0039] 1. Accurately weigh tramadol hydrochloride and acetaminophen raw materials according to the above prescription ratio.

[0040] 2. Put tramadol hydrochloride into 1200ml of water for injection heated to about 60°C, stir until completely dissolved, adjust the pH value to 4.5-6.5, and obtain liquid A for later use.

[0041] 3. Put acetaminophen into 3000ml water for injection, stir until it is completely dissolved, adjust the pH value to 4.5-6.5, and obtain liquid B for later use.

[0042] 4. Mix liquid A and liquid B evenly, and add water to the full volume of 3000ml.

[0043] 5. Add 0.01-0.5% activated carbon f...

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PUM

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Abstract

The present invention relates to an injection preparation formed from tramadol hydrochloride and paracetamol. It is a new analgetic medicine with the effect of quickly-stopping pain.

Description

technical field [0001] The invention relates to a new injection for clinical analgesia in the field of medicine, which is composed of tramadol hydrochloride and acetaminophen. Background technique [0002] Pain is the earliest subjective inner feeling that humans can perceive, and it is also the most frequently encountered problem for humans. However, people have a one-sided understanding of pain for a long time, thinking that pain is only a symptom of the disease, and as long as the disease is cured, the pain will disappear, so there are still many patients who are suffering from pain. As a disease, chronic pain has attracted great attention all over the world. The World Pain Congress recognized pain as the "fifth vital sign of human beings" after breathing, pulse, body temperature and blood pressure. Many pathological pain itself is a disease that seriously affects the quality of life and work of patients. People gradually realize the importance of pain. The World Health ...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K9/08A61K9/14A61K9/19A61P25/04A61P29/00A61K31/137
Inventor 陈旭良
Owner 陈旭良
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