Oral disintegrating tablet containing tramadol hydrochloride and acetaminopher, and its preparation method

Abstract

The invention provides an orally disintegrating tablet containing tramadol hydrochloride and paracetamol, and the preparing process, wherein tramadol hydrochloride and paracetamol are dressed for mouth cavity use. During the dressing process, right amount of medicinal auxiliary materials are charged.

Description

technical field [0001] The invention relates to a preparation containing tramadol hydrochloride and acetaminophen and a preparation method thereof, in particular to an orally disintegrating tablet containing tramadol hydrochloride and acetaminophen and a preparation method thereof. technical background [0002] Tramadol hydrochloride is a synthetic opioid central analgesic, its spatial structure is similar to the partial structure of endorphin, it can also specifically bind to opioid receptors, stimulate receptors, and produce morphine-like analgesic effects, but without morphine The same serious adverse reactions, under the therapeutic dose, the tolerance is better, the dependence is low, because there is no adrenergic and serotonergic effects, respiratory depression, constipation, dysuria will not occur, and the blood vessels, liver and kidney functions will not be affected. , smooth muscle and striated muscle, etc. There is no adverse effect, the onset is fast and the dur...

AI Technical Summary

Problems solved by technology

[0006] However, the tramadol hydrochloride / acetaminophen compound tablets currently on the market are ordinary tablets, which need to be swallowed with water when taking them. Once pain occurs, they cannot be taken in time, and the pain cannot be relieved in time. It needs to be excreted through the gastrointestinal tract. Absorption, low bioavailability, large side effects;

[0007] At the same time, it is impossible to form orally disintegrating tablets with tramadol hydrochloride and acetaminophen by conventional methods, because tramadol hydrochloride and / or acetaminophen are extremely bitter drugs, and generally do not make orally disintegrating tablets

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