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Method of preparing nano medical adhesive

A kind of adhesive, nano technology, applied in the field of preparation of nano medical adhesive, can solve the problems of insufficient bonding strength, low viscosity, non-degradable, etc., and achieve high bonding strength, high compressive strength, and less irritation Effect

Inactive Publication Date: 2018-10-30
SUZHOU JONATHAN NEW MATERIALS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the adhesives commonly used in the medical field have some shortcomings, such as low viscosity, insufficient bonding strength, single function, and non-degradable, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] A method for preparing a nanometer medical adhesive, the method comprising the following steps: weighing each raw material by weight: 55 parts of polyvinylpyrrolidone, 8 parts of polyethersulfone ether ketone, 50 parts of polyvinyl alcohol, 25 parts of xanthan gum 3 parts of agar, 10 parts of fibrin glue, 5 parts of sweet potato starch, 3 parts of ethyl acetate, 4 parts of nano-calcium oxide powder, 2 parts of sodium glycocholate, 3 parts of triglycerol monostearate, koji hydrochloride 5 parts of Mado, 10 parts of polyether trihydric alcohol, 3 parts of zinc oxide, 5 parts of sodium carboxymethyl cellulose, 15 parts of sodium alginate, 11 parts of cellulose, put the raw materials into the container, and ultrasonicate at room temperature for 1- After 6 hours, heat to 80°C, stir for 1-3 hours, and then carry out disinfection treatment.

[0012] The ultrasonic frequency is 30-50KHz.

[0013] The stirring speed is 200-400 rpm.

[0014] The zinc oxide is nano zinc oxide. ...

Embodiment 2

[0016] A method for preparing a nanometer medical adhesive, the method comprising the following steps: weighing each raw material by weight: 65 parts of polyvinylpyrrolidone, 15 parts of polyethersulfone ether ketone, 60 parts of polyvinyl alcohol, 40 parts of xanthan gum 8 parts of agar, 15 parts of fibrin glue, 10 parts of sweet potato starch, 8 parts of ethyl acetate, 6 parts of nanometer calcium oxide powder, 6 parts of sodium glycocholate, 5 parts of tripolyglycerol monostearate, koji hydrochloride 8 parts of Mado, 15 parts of polyether trihydric alcohol, 5 parts of zinc oxide, 10 parts of sodium carboxymethyl cellulose, 20 parts of sodium alginate, and 14 parts of cellulose, put the raw materials into the container, and ultrasonicate at room temperature for 1- After 6 hours, then heat to 100°C, stir for 1-3 hours, and then carry out disinfection treatment.

[0017] The ultrasonic frequency is 30-50KHz.

[0018] The stirring speed is 200-400 rpm.

[0019] The zinc oxide...

Embodiment 3

[0021] A method for preparing a nanometer medical adhesive, the method comprising the following steps: weighing each raw material by weight: 60 parts of polyvinylpyrrolidone, 12 parts of polyethersulfone ether ketone, 55 parts of polyvinyl alcohol, 32 parts of xanthan gum 5 parts of agar, 13 parts of fibrin glue, 7 parts of sweet potato starch, 5 parts of ethyl acetate, 5 parts of nano-calcium oxide powder, 4 parts of sodium glycocholate, 4 parts of triglycerol monostearate, koji hydrochloride 7 parts of Mado, 13 parts of polyether trihydric alcohol, 4 parts of zinc oxide, 7 parts of sodium carboxymethyl cellulose, 18 parts of sodium alginate, and 13 parts of cellulose, put the raw materials into the container, and ultrasonicate at room temperature for 1- After 6 hours, heat to 90°C, stir for 1-3 hours, and then perform disinfection treatment.

[0022] The ultrasonic frequency is 30-50KHz.

[0023] The stirring speed is 200-400 rpm.

[0024] The zinc oxide is nano zinc oxide...

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Abstract

The invention discloses a method of preparing nano medical adhesive. The nano medical adhesive is made from the following parts, by weight, of 55-65 parts of polyvinylpyrrolidone, 8-15 parts of polyethersulfone ether ketone, 50-60 parts of polyvinyl alcohol, 25-40 parts of xanthan gum, 3-8 parts of agar, 10-15 parts of fibrin glue, 5-10 parts of sweet potato starch, 3-8 parts of ethyl acetate, 4-6parts of nano-calcium oxide powder, 2-6 parts of sodium glycocholate, 3-5 parts of triglyceride monostearate, 5-8 parts of tramadol hydrochloride, 10-15 parts of polyether triol, 3-5 parts of zinc oxide, 5-10 parts of sodium carboxymethyl cellulose, 15-20 parts of sodium alginate and 11-14 parts of cellulose. The prepared nano medical adhesive has the advantages of having high bond strength and compressive strength and little stimulation to organism tissues, adding no harmful reagents, having antibacterial hemostasis, and being suitable for use in surgery and especially suitable for the bonding of soft tissues.

Description

technical field [0001] The invention relates to a preparation method of a nanometer medical adhesive. Background technique [0002] The existing means of repairing human tissue trauma include surgical sutures, medical tapes and medical adhesives. Surgical sutures cause pain to the patient when used, are difficult to repair microtrauma, and easily cause infection. The strength of medical tape is too low and its adaptability to complex wounds is poor. Medical adhesives can strongly bond body tissues with fast bonding speed, are non-toxic, have little reaction to tissues, will not cause thrombus, and can be easily sterilized. Medical adhesives are mainly used in various surgical operations such as various trauma wounds, surgical cosmetic surgery, and family planning. They can quickly bond human biological tissues and promote wound healing, and can partially replace wound sutures. The use of medical adhesives has a long history and plays a very important role in clinical pra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/06A61L24/04A61L24/02A61L24/00
CPCA61L24/001A61L24/0015A61L24/02A61L24/046A61L24/06A61L24/08A61L24/106A61L2300/404A61L2400/04A61L2400/12C08L39/06C08L29/04C08L81/06C08L5/00C08L5/12C08L3/02C08L71/02C08L1/286C08L5/04C08L1/02
Inventor 吕少波李卓才李苏杨
Owner SUZHOU JONATHAN NEW MATERIALS TECH
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