Purpose of toluylene glycosides and its derivant for restraining synapse ribonucleoprtein excess expression

A technology of stilbene glycoside and synuclein, which is applied in the directions of drug combination, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of not finding stilbene glycoside α-synuclein and the like

Active Publication Date: 2008-04-16
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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  • Abstract
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Problems solved by technology

[0011] Stilbene glucoside is one of the main active ingredients of the traditional Chinese medicine Polygonum multiflorum. Previous studies have found that this type of compound has a good protective effect on animal cerebral ischemia injury, and at the same time has a good effect on animal models of dementia caused by various factors. So far So far, there is no report on the pharmacological function of stilbene glycosides that can effectively inhibit the overexpression of α-synuclein in vivo

Method used

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  • Purpose of toluylene glycosides and its derivant for restraining synapse ribonucleoprtein excess expression
  • Purpose of toluylene glycosides and its derivant for restraining synapse ribonucleoprtein excess expression

Examples

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Embodiment 1

[0020] The preparation of embodiment 1 tablet

[0021] Stilbene glycosides 50mg, carboxymethylcellulose 240mg, lactose 100mg, magnesium stearate 10mg. The above-mentioned components are pulverized, mixed, and compressed into tablets.

Embodiment 2

[0022] The preparation of embodiment 2 injection

[0023] Mix 25 mg of stilbene glycoside and 100 mL of normal saline to make an injection.

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Abstract

Application of stilbene glucoside or its derivative in inhibiting alpha-synuclein over expression is disclosed in the present invention. As the result of the test shows, stilbene glucoside or its derivative can effectively inhibit alpha-synuclein over expression, can be used for treating or preventing a plurality of nervous system diseases such as Parkinson's disease, dementia with Lewy body, simple autonomic nerve dysfunction, multiple system atrophy and etc. caused by alpha-synuclein over expression.

Description

technical field [0001] The invention relates to a new medical application of stilbene glycoside or its derivatives, in particular to the application of stilbene glycoside or its derivatives in inhibiting the overexpression of α-synuclein, and belongs to the field of medicinal chemistry. Background technique [0002] The structural formula of stilbene glycoside (2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, TSG) is as follows: [0003] [0004] wherein R is -O-β-D-glucose. [0005] Stilbene glycosides can be directly purchased in the market, and their content can be analyzed by high performance liquid chromatography. [0006] Synuclein (synuclein) is a small synaptic protein isolated from the charged organs of the Pacific electric sturgeon (Torpedo caIifornia). It is named because it is mainly located on the nerve synapse and the nuclear membrane. Studies have shown that some autosomal dominant familial Parkinson's diseases are associated with three gene missense muta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P25/00A61P25/16A61P25/28
Inventor 李林张兰魏海峰刘莹
Owner XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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