Application for preparing therapy antiarrhythmic medicament of Zacopride
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of arrhythmia and Zacobili, which is applied in the field of medicine and can solve problems such as arrhythmia
Inactive Publication Date: 2008-06-18
SHANXI MEDICAL UNIV
View PDF0 Cites 3 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0032] The present invention all has certain arrhythmogenic effect in order to solve existing antiarrhythmic drugs, and has not yet found I at home and abroad so far. K1 The problem of
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0071] Embodiment 1: the influence of Zacopride (Zacopride on the ion channel current of ventricular myocytes
[0072] 1 Materials and methods:
[0073] 1.1 Experimental animals:
[0074] Healthy SD rats, male, weighing 220-260 g, were purchased from the Experimental Animal Center of Zhengzhou University, Henan.
[0075] 1.2 Drugs and reagents:
[0076] Zacopride hydrochloride was purchased from TOCRIS. Collagenase P was purchased from Bochringer Mannhein, Germany, taurine, tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP), nicardipine, adenosine triphosphate Sodium salt (adenosine 5'-triphosphate disodium salt), adenosine triphosphate dipotassium salt (adenosine 5'-triphosphate dipotassium salt), adenosine triphosphate magnesium salt (adenosine 5'-triphosphatemagnesium salt), DL-aspartic acid potassium salt (DL-aspartic acid acid potassium), L-glutamic acid (L-glutamic acid), Ethylene Glycol-bis (beta-aminoethyl-ether)-N, N, N', N'-Tetra Acetate (EGTA), creatine p...
Embodiment 2
[0141] Example 2: Research on the effect of Zacopride on anti-ischemic and reperfusion arrhythmias in rats
[0142] 1 Materials and methods
[0143] 1.1 Experimental animals:
[0144] Healthy SD rats, male, weighing 220-260 g, were purchased from the Experimental Animal Center of Zhengzhou University, Henan.
[0145] 1.2 Drugs and reagents:
[0146] Zacopride hydrochloride was purchased from TOCRIS. Lidocaine hydrochloride injection was purchased from Shanghai Xudong Haipu Pharmaceutical Co., Ltd.
[0147] 1.3 Main instruments:
[0148] Rm6240 multi-channel physiological signal acquisition and processing system (Chengdu Instrument Factory); HX-200 animal ventilator (Chengdu Taimeng Technology Co., Ltd.)
[0149] 1.4 Reagent preparation:
[0150] 1.4.1 Solution preparation:
[0151] 1. Zacopride stock solution: Dissolve zacopride in deionized water to a concentration of 1 mmol / L. Dilute as needed when using. .
[0152] 2. Lidocaine stock solution (0.1g / 5ml): Take it a...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to the medicine field, particularly relating to a drug for treating arrhythmia, in particular to an application of Zacopride in preparing a drug for treating the arrhythmia. The invention aims at solving the problems that the present antiarrhythmic drugs have the effect of causing arrhythmia, and IK1 selective agonist has not been discovered at home and abroad so far. The Zacopride is an IK1 selective agonist which is discovered at present for the first time and is used on an antiarrhythmic drug. Used as a drug for treating ischemia-reperfusion arrhythmia, the Zacopride has the similar effect to that of lidocaine, takes effect stably and does not obviously affect the rhythm with wide safety range. In the experiments of arrhythmia induced by ischemia-reperfusion, lidocaine can make the rhythm slower, while the Zacopride has no obvious effect; and when the dosage of the lidocaine is increased by one-third, the antiarrhythmic effect is obviously weakened, while such phenomenon occurs when the Zacopride reaches one hundred times of effective concentration.
Description
technical field [0001] The invention relates to the field of medicine, and mainly relates to a medicine for treating arrhythmia, in particular to the application of Zacopride as a medicine for treating arrhythmia. Background technique [0002] Arrhythmia refers to the abnormality of heartbeat frequency and rhythm. Arrhythmia is a common cardiovascular disease in clinical practice. Severe arrhythmia is often one of the main causes of death of patients. [0003] Myocardial ischemia, hypoxia, acidosis / alkalosis, electrolyte disturbance, drug poisoning, myocardial injury, etc. can all induce arrhythmia. The basic mechanisms of arrhythmia are reentry, abnormal automaticity and triggered activity. That is, all arrhythmias are caused by impulse conduction disorders, impulse formation disorders, or both. The mechanism of severe arrhythmia is very complicated, and it is often not a single mechanism, but at its root, there is a change in the functional activity of ion channels. Or ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more