Soft capsule for hepatitis and preparation method thereof
A soft capsule, Yinzhihuang technology, applied in the field of Yinzhihuang soft capsule preparation, can solve the problems of unqualified soft capsule disintegration, effective ingredient sedimentation, capsule material migration, etc., achieves significant stability and therapeutic advantages, and enhances beneficial effects. effect of effect
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Embodiment 1
[0119] Example 1: Preparation of four kinds of extracts in Yinzhihuang extract
[0120] Preparation of capillary extract: take capillary, add water and decoct three times, the first time is 1.5 hours, the second and third time are 1 hour each, combine the decoction, filter, the filtrate is concentrated to contain 2g of crude drug per ml, add ethanol Make the alcohol content reach 70%, refrigerate for 24 hours, filter, recover ethanol from the filtrate to contain 5g of crude drug per ml, add ethanol to make the alcohol content reach 85%, refrigerate for 24 hours, filter, recover ethanol from the filtrate to contain 10g of crude drug per ml , add about 5 times the amount of water, refrigerate for 48 hours, filter, the filtrate is concentrated into a thick paste, and vacuum-dried to obtain the capillary extract.
[0121] Preparation of gardenia extract: Take gardenia, crush it into a coarse powder, add water to decoct three times, the first and second times each for 1 hour, and t...
Embodiment 2
[0125] Capillary extract: 0.06g
[0126] Gardenia Extract: 0.032g
[0127] Baicalin: 0.2g
[0128] Honeysuckle extract: 0.04g
[0129] Soybean oil: 0.22g
[0130] Tween-80: 0.05g
[0131] Beeswax: 0.02g
[0132] Hydrogenated palm oil: 0.02g
[0133] Soy lecithin: 0.008g
[0134] Make 1 capsule (0.65g)
[0135] Preparation Process
[0136] Take the prescribed amount of Tween-80 and soybean lecithin, stir well until the mixture is uniform, and use it as spare solution 1.
[0137] Take the capillary extract, gardenia extract, baicalin and honeysuckle extract in Example 1, grind them into fine powders that can pass through a 200 mesh sieve, add them to the above-mentioned standby solution 1, fully disperse and stir evenly, and the dispersion time must not Less than 20 minutes, as stock solution 2.
[0138] Take the prescribed amount of soybean oil, add beeswax and hydrogenated palm oil, heat to melt the suspending agent, stir evenly, let cool to about 50 degrees; pour th...
Embodiment 3
[0140] Capillary extract: 0.06g
[0141] Gardenia Extract: 0.032g
[0142] Baicalin: 0.2g
[0143] Honeysuckle extract: 0.04g
[0144] Corn oil: 0.31g
[0145] Tween-80: 0.04g
[0146] Beeswax: 0.04g
[0147] Hydrogenated coconut oil: 0.01g
[0148] Soy lecithin: 0.02g
[0149] Make 1 capsule (0.75g)
[0150] Preparation Process
[0151] Take the prescribed amount of Tween-80 and soybean lecithin, stir well until the mixture is uniform, and use it as spare solution 1.
[0152] Take the capillary extract, gardenia extract, baicalin and honeysuckle extract in Example 1, grind them into fine powders that can pass through a 180 mesh sieve, add them to the above-mentioned standby solution 1, fully disperse and stir evenly, and the dispersion time must not Less than 20 minutes, as stock solution 2.
[0153] Take the prescribed amount of corn oil, add beeswax and hydrogenated coconut oil, heat to melt the suspending agent, stir evenly, let cool to about 45 degrees; pour the...
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