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Preparation method of salvia miltiorrhiza tanshinoate A

A technology of salvianolic acid and salvia miltiorrhiza, applied in the field of preparation of salvianolic acid A, can solve the problems of unrealizable, unobtainable salvianolic acid A, low extraction rate, etc.

Inactive Publication Date: 2008-07-30
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing documents and patents disclose the extraction and purification process of salvianolic acid A. Although salvianolic acid A can be obtained, the focus is on how to separate salvianolic acid A from impurities. It is very low, it cannot be realized in industrial production, and it is also impossible to obtain "pharmaceutical" grade salvianolic acid A. This is a difficulty facing many scientific researchers.

Method used

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  • Preparation method of salvia miltiorrhiza tanshinoate A
  • Preparation method of salvia miltiorrhiza tanshinoate A
  • Preparation method of salvia miltiorrhiza tanshinoate A

Examples

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Effect test

Embodiment 1

[0090] Method 1: Extract the salvia miltiorrhiza with water to obtain the water extract, adjust the pH value to 3.5 and 110°C, heat for 1 hour, filter the solution, concentrate and dry the filtrate, and obtain the salvianolic acid A extract;

[0091]Method 2: Extract the salvia miltiorrhiza with water to obtain the water extract, adjust the pH value to 3.5, put it into a microwave extractor, extract it with a microwave with a frequency of 915 MHz and a power of 1000 watts for 0.5 hours, filter the extract, concentrate and dry the filtrate, and obtain salvianolic acid A extract;

[0092] Method 3: extract the salvia miltiorrhiza with water to obtain the water extract, adjust the pH value to 3.5 and 110°C, heat for 1 hour, filter the solution, and separate the filtrate through HPD-100 macroporous resin column chromatography, wash with water and 10% dilute ethanol first stripping, removing impurities, and then eluting with 30% ethanol, collecting the eluent, recovering the ethano...

Embodiment 2

[0096] Method 1: Extract Danshen with 70% ethanol solution to obtain alcohol extract, concentrate ethanol to the maximum in alcohol extract, adjust the pH value to 4.5 and 120°C, heat for 3 hours, filter the solution, concentrate and dry the filtrate, and obtain salvianolic acid A extract;

[0097] Method 2: Extract Danshen with 70% ethanol solution to obtain alcohol extract, concentrate the ethanol to the maximum in alcohol extract, adjust the pH value to 4.5, put it into a microwave extractor, and extract it with a microwave with a frequency of 2450 MHz and a power of 10000 watts for 1 hour. liquid filtration, and the filtrate was concentrated and dried to obtain the salvianolic acid A extract;

[0098] Method 3: Extract Danshen with 70% ethanol solution to obtain alcohol extract, concentrate the ethanol to the maximum in the alcohol extract, adjust the pH value to 4.5 and 120°C, heat for 3 hours, filter the solution, and pass the filtrate through HPD-300 macroporous resin c...

Embodiment 3

[0102] Method 1: Extract Danshen with 80% ethanol solution to obtain alcohol extract, concentrate ethanol to the end of alcohol extract, adjust pH value to 6.0, 130°C temperature, heat for 6 hours, filter the solution, concentrate and dry the filtrate to obtain salvianolic acid A extract;

[0103] Method 2: Salvia miltiorrhiza is extracted with 80% ethanol solution to obtain an alcohol extract, the alcohol extract is concentrated with ethanol to the utmost, the pH value is adjusted to 6.0, put into a microwave extractor, the frequency is 2450MHz, and the power is 15000 watts of microwave extraction for 2 hours, extract liquid filtration, and the filtrate was concentrated and dried to obtain the salvianolic acid A extract;

[0104] Method 3: Extract Danshen with 80% ethanol solution to obtain alcohol extract, concentrate the ethanol to the maximum, adjust the pH value to 6.0, 130°C, heat for 6 hours, filter the solution, and pass the filtrate through HPD-400A macroporous resin ...

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Abstract

The invention discloses a method for manufacturing salvianolic acid A of danshen root, which is characterized in that total salvianolic acid in the danshen root is transformed into salvianolic acid A by adopting a certain method. The method increases greatly the extraction yield of salvianolic acid A. The salvianolic acid A is prepared into tablets, capsule, granula, soft capsule, micro pill, dripping pill and oral liquid, which have good pharmacological action indicated by pharmacological experiments.

Description

technical field [0001] The invention relates to the technical fields of medicine and health food, in particular to a preparation method of salvianolic acid A. Background technique [0002] Salvia miltiorrhiza is the root of Salvia miltiorrhiza in the family Lamiaceae. Bitter in taste and slightly cold in nature, salvia miltiorrhiza is one of the most commonly used medicinal materials. It is used to treat cardiovascular and cerebrovascular diseases such as angina pectoris, hypertension, coronary heart disease and stroke. It is a commonly used medicinal flavor of traditional Chinese medicine for promoting blood circulation and removing blood stasis. [0003] The chemical components of Salvia miltiorrhiza can be divided into water-soluble components and fat-soluble components. Most of the water-soluble components of Salvia miltiorrhiza have a phenolic acid structure, that is, active ingredients such as salvianolic acids A, B, C, D, and E. Among the total phenolic acids of Salv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/48A61K31/216A61K36/53
Inventor 李志刚顾群渠守峰
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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