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Method for preparing metronidazole furanzolidon vaginal tablet and quality control method

A technology of metronidazole, furazolidone, and quality control methods, applied in the field of new antibacterial and anti-inflammatory drugs for gynecology, can solve the problems of hand contact with contaminated drugs, drug melt outflow, slow drug dispersion, etc., to promote disease recovery, reduce adverse reactions, and drug The effect of high effective concentration

Inactive Publication Date: 2008-08-06
屠瑞丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many types of gynecological drugs, there are certain problems in their use and treatment. In addition, metronidazole furazolidone suppositories are currently on the market, which has the problems of hand contact with contaminated drugs, drug melt out, contaminated clothes, and slow drug dispersion.

Method used

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Examples

Experimental program
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Effect test

Embodiment

[0020] Example: (1) prescription metronidazole 5.2g, furazolidone 5.2g, alum 79g, borneol 1.2g, frankincense 11g, polyethylene glycol 40006g, lactose 80g, starch 200.0g, hypromellose 2.0g, dioxide Silicon 20.0g, microcrystalline cellulose 60.0g crospovidone 60g (plus 20g), magnesium stearate 2.0g.

[0021] (2) Method

[0022] A Pretreatment: In addition to polyethylene glycol 4000 and borneol, metronidazole, furazolidone, alum, frankincense, lactose, starch, silicon dioxide, crospovidone, microcrystalline cellulose, and magnesium stearate were subjected to necessary crushed and passed through a No. 7 sieve respectively.

[0023] Preparation of B metronidazole furazolidone vaginal tablet granules: Weigh polyethylene glycol 4000 of prescription quantity, heat and melt, add borneol and mix, cool, pulverize through 80 mesh sieve, mix with metronidazole, furazolidone, alum, frankincense and lactose, 40g of starch, microcrystalline cellulose, and crospovidone, using 2% hypromellos...

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Abstract

The invention relates to a method for preparing novel gynecological metronidazole furazolidone vaginal tablet used for antisepsis and anti-inflammation and a quality control method thereof. The medicine is used for curing cervicitis, cervical erosion, trichomonas vaginitis, bacterial vaginosis and colpitis mycotica. The invention has the advantages that vagina local medication avoids or reduces possible untoward effect caused by systemic administration; highly effective concentration of the medicine on lesion site is in favor of developing therapeutic effect. Prescription of 1,000 preparation units of the medicine is: 3-26g of metronidazole, 3-26g of furazolidone, 40-395g of alumen, 0.6-6g of borneol, 6-55g of frankincense, 40,003-30g of polyethylene glycol, 40-400g of lactose, 50-500g of starch, 1-30g of hypromellose, 10-100g of silicon dioxide, 30-300g of microcrystalline cellulose, 30-300g of polyvinyl polypyrrolidone (additionally provided 10-100g) and 1-20g of magnesium stearate.

Description

technical field [0001] The invention relates to a preparation method and a quality control method of metronidazole furazolidone vaginal tablets, a new antibacterial and anti-inflammatory drug for gynecology. Background technique [0002] At present, trichomonas, anaerobes, molds and other bacterial infectious gynecological diseases seriously threaten women's health. Although there are many types of gynecological drugs, there are certain problems in their use and treatment. In addition, metronidazole furazolidone suppositories are currently on the market, which has the problems of hand contact with contaminated drugs, drug melt out, contaminated clothes, and slow drug dispersion. [0003] The purpose of the present invention is to overcome the shortcomings of the existing varieties, provide a novel preparation with spectrum, high efficiency, quick effect, stability and good patient compliance and provide a quality control method. Contents of the invention [0004] The pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4164A61K31/422A61P15/02
Inventor 王世锋屠瑞丽
Owner 屠瑞丽
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