Method of preparing micro needle array syringe

A technology for microneedle arrays and syringes, which is applied in the field of preparation of microneedle array syringes, can solve the problems of impossibility to apply low-cost hollow microneedle arrays, limit the application field and scope, etc., achieve short preparation cycle, reduce preparation cost, and simple operation Effect

Inactive Publication Date: 2008-08-06
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current preparation of hollow microneedle arrays mainly relies on expensive microfabrication techniques, such as reactive ion beam etching, focused ion beam etching, etc., and in order to prevent infection, contamination, etc., microneedle arrays are usually disposable. Therefore, the above method cannot be applied to the preparation of cheap hollow microneedle arrays that are generally available in the market, which greatly limits its application field and scope

Method used

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  • Method of preparing micro needle array syringe
  • Method of preparing micro needle array syringe

Examples

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Embodiment 1

[0022] Example 1: SiO with a fiber diameter of 100 microns 2 Put the fiber bundle into the MMA (polymethyl methacrylate) solution added with BPO, place it in a water bath at 60 ° C for 24 h to cure the polymer, and then cut it into thin slices with a thickness of 5 mm, and use 40% HF acid solution for 30 Corrosion at a constant temperature of ℃ for 1 h, ultrasonic cleaning with deionized water, and drying to obtain the nanoneedle array. Then put into the chloroform solution and dissolve for 20min, after drying, use the spin coating method to spin-coat PMMA with a thickness of 20um on the surface, put it into a 40% HF acid corrosion solution and corrode it for 5h at a temperature of 30°C to obtain the PMMA material. Hollow Microneedle Array Syringes.

Embodiment 2

[0023] Embodiment 2: SiO with a fiber diameter of 8 microns 2 Put the fiber bundle into a styrene solution with lithium hexamethyleneimide, place it in a water bath and heat treat at 60°C for 24 hours to solidify the polymer; then cut it into thin slices with a thickness of 3mm; use 20% The HF acid solution was corroded for 30 min, and the nanoneedle array was obtained after ultrasonic cleaning with deionized water and drying. Then it was dissolved in chloroform solution for 5 minutes, after drying, Au with a thickness of 1 um was deposited on the surface by magnetron sputtering method, and it was put into a 40% HF acid corrosion solution and corroded at 30 ° C for 5 hours to obtain PS as Au-based hollow microneedle array injectors.

Embodiment 3

[0024] Embodiment 3: SiO with a fiber diameter of 20 microns 2 The fiber bundles were immersed in molten polystyrene (PS) resin at 120°C, cooled and sectioned after filling, corroded with 40% HF acid solution for 10 min at a constant temperature of 40°C, ultrasonically cleaned with deionized water, and microneedle arrays were obtained after drying. Then place it on the surface of the polydimethylsiloxane film at 90°C for embossing, then deposit Au with a thickness of 2um on the surface by electroless plating, put it into a 20% HF acid etching solution and etch it at 40°C for 8h , to obtain PS-based Au hollow microneedle array injectors.

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Abstract

The invention discloses a preparation method for a micro-needle array injector, which belongs to a field of biological medical apparatus. The method of the invention adopts micrometer fibers and sub-micrometer fibers as a master plate and obtains the high quality micro-needle array injector with controllable length and hollow internal parts through the steps such as the preparation of micro-needle arrays, the control of the length of the micro-needle, the preparation of shell structures of the surface of the micro-needle and the preparation of the hollow structure. The preparation method provided by the invention has the advantages of cheapness, no need of complicated devices or technology, mass fast production, large needle array area and adjustable diameters and lengths. Through the application of the technology, the high-quality cheap micro-needle array injector can be obtained, which leads the expensive skin permeation technology in the field of biological medicine to the mass market through the cost degradation of the micro-needle array injector.

Description

technical field [0001] The invention relates to a preparation method of nanometer and micron microstructure materials, in particular to a preparation method of a microneedle array injector. Background technique [0002] Transdermal drug delivery is a new way of non-invasive drug delivery. Because the drug absorption is not affected by the stomach, intestinal tract and other digestive tracts, and avoids the first-pass effect of the liver and gastrointestinal tract, it has received widespread attention at home and abroad. Broad market prospects. The stratum corneum of the skin is the main barrier for drugs to enter the body, so the key to transdermal drug delivery is how to break through the stratum corneum and avoid skin irritation. Among them, the microneedle array method has attracted the most attention, that is, the microneedle is used to penetrate the stratum corneum of the skin without injuring the dermis for drug delivery. The pores produced by microneedle arrays are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/178A61M37/00B81C5/00B01J19/00B81C99/00
CPCA61M37/0015A61M2037/0053
Inventor 祝名伟陈延峰王振林陆延青葛海雄
Owner NANJING UNIV
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