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Rare earth complex, preparation method and antibiotic application of the same

A technology of rare earth complexes and rare earth chlorides, applied in botany equipment and methods, chemicals for biological control, applications, etc., can solve the problems of unsatisfactory external drugs, strong acidity of the solution, etc., and achieve good antibacterial performance , a wide range of antibacterial effects

Inactive Publication Date: 2008-08-06
HEBEI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current research is mainly focused on the synthesis of simple rare earth inorganic or organic salts. Although they have strong antibacterial properties and a wide antibacterial spectrum, the acidity of the solution is strong, which is not ideal as an external drug.

Method used

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  • Rare earth complex, preparation method and antibiotic application of the same
  • Rare earth complex, preparation method and antibiotic application of the same

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 rare earth complex

[0026] One, the structural formula of the rare earth complex provided by the present invention is: RE L 3 phen nH 2 O;

[0027] Where RE: can be Eu in rare earth elements 3+ , Tb 3+ 、Gd 3+ , La 3+ , Y 3+ Any one of; n=0 or 1;

[0028] L is the first ligand: L can be used as one of the four naphthoic acids, α-Naphthoic acid, β-Naphthoic acid, α-Naphthlcetic acid, and β-Naphthlcetic acid. The Chinese names of the four kinds of naphthoic acids are α-naphthalene Formic acid, β-naphthoic acid, α-naphthylacetic acid, β-naphthylacetic acid;

[0029] Phen is the second ligand: Phen is the abbreviation of 1,10-phenanthroline (1,10-phenanthroline), and its chemical formula is C 12 h 8 N 2 ; There are 19 complexes in total, and the composition and chemical formula of the rare earth complexes are listed in the following table:

[0030] Table 1: Composition and chemical formula list of the synthesized rare earth comple...

Embodiment 2

[0038] Embodiment 2 antibacterial test

[0039] 1. Qualitative antibacterial experiment

[0040] Using DMF (N, N-dimethylformamide) as a solvent, prepare 0.012mol / L of 5 kinds of rare earth ions Eucl 3 , Tbcl 3 , Gdcl 3 、LaCl 3 , YCl 3 ·6H 2 O, 5 ligands α-NAA, β-NAA, α-NMA, β-NMA, phen, and Eu(α-NMA) 3 phen H 2 O, Tb(α-NMA) 3 phen H 2 O, Gd(α-NMA) 3 phen H 2 O, La(α-NMA) 3 phen, Y(α-NMA) 3 phen, Eu(β-NMA) 3 phen, Tb(β-NMA) 3 phen, Gd(β-NMA) 3 phen, Y(β-NMA) 3 phen, Eu(α-NAA) 3 phen, Tb(α-NAA) 3 phen, Gd(α-NAA) 3 phen, La(α-NAA) 3 phen, Y(α-NAA) 3 phen, Eu(β-NAA) 3 phen, Tb(β-NAA) 3 phen, Gd(β-NAA) 3 phen H 2 O, La(β-NAA) 3 phen, Y(β-NAA) 3 phen solution.

[0041] Prepare Mueller-Hinton Agar (MHA) medium, dissolve each 38g in 1L of water, sterilize at 121°C for 20min, and pour the plate. Streak inoculation of test bacteria Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa, Bacillus subtilis, Aeromonas sobri...

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Abstract

The invention discloses a naphthoic acid and 1, 10-o-phenanthroline rare-earth complex and its function for inhibiting bacterial, which is represented as REL3phen nH2O, wherein RE is rare-earth element as Eu3+, Tb3+, Gd3+, La3+ or Y3+, L is one of alpha-Naphthoic acid, beta-Naphthoic acid, alpha-Naphthlcetic acid and beta-Naphthlcetic acid, n=0 or 1. The preparation method comprises using L as first ligand and o-phenanthroline as second ligand while RE3+: L: phen is 1:3:1, adding alcohol and dissolving, mixing the two ligands to be added into a rare-earth chloride solution, mixing and reacting to synthesize rare-earth complex. The qualitative and quantitative bacteriostatic tests of filter paper method on the rare-earth complex prove that the rare-earth complex has bacteriostatic function on variable experimental bacteria, stronger than independent ligand and ion and stronger bacteriostatic effect along with density increase. The invention provides useful try for biological bacteria inhibitor development.

Description

technical field [0001] The invention relates to a rare earth complex, in particular to a rare earth complex with naphthoic acid and 1,10-phenanthroline as ligands, and belongs to the technical field of microbial antibacterial. Background technique [0002] Rare earths have a unique electronic layer and nuclear structure, and have good antibacterial, anti-inflammatory, and anti-tumor effects. my country's reserve resources account for about 80% of the world. Since the 20th century, research on rare earths in the field of life sciences has been continuously reported. Due to their low toxicity, the antibacterial properties of rare earths have good application prospects in agriculture, medical care and health. For example, cerium nitrate has been used as a bactericidal and anti-inflammatory agent. In clinical practice, it has a good therapeutic effect on burns. Rare earth can improve the disease resistance of crops by inhibiting the growth and reproduction of pathogenic bacteri...

Claims

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Application Information

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IPC IPC(8): C07F5/00A01N55/02A01P1/00A61K31/555A61P31/00
Inventor 赵宝华王瑞芬杨楠项楠杨凯范琼英
Owner HEBEI NORMAL UNIV
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