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Multidrug resistant anticancer anthracyclines

By structurally modifying the sugar moiety of anthracyclines, new anthracyclines are designed, which solve the problems of drug resistance and cardiotoxicity and significantly improve the effectiveness of cancer treatment, especially in drug-resistant cell lines.

Inactive Publication Date: 2008-08-06
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Despite widespread use of anthracyclines in cancer therapy, drug resistance and cardiotoxicity limit their clinical utility

Method used

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Embodiment Construction

[0029] In the present invention, certain synthetic anthracyclines can be viewed as analogs of daunorubicin (DNR) and doxorubicin (DOX) with uncommon sugars, which have been shown to be effective in the treatment of multiple Improved efficacy in cancer treatment. These rare sugars can be either monosaccharides or disaccharides, in which the proximal sugar group is replaced by an azide group, an alkyltriazole group or a combination of Me, OH and OMe groups, different from Known DOX and DNR compounds.

[0030] As used herein, "treat (verb)" means to cure, ameliorate or alleviate the severity of cancer and the symptoms associated therewith. As used herein, the terms "treat (verb)", "treatment (noun)" and "therapy" refer to curative therapy, prophylactic therapy and preventive therapy.

[0031] "Prevention (verb)" or "prevention (noun)" means preventing the occurrence of cancer or mitigating the severity of cancer by taking medication immediately after it occurs. This completely...

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Abstract

Synthesized novel anthracycline compounds with uncommon sugars exhibit enhanced effectiveness in treating various drug-resistant cancers.

Description

[0001] government rights [0002] The work described here was supported, at least in part, by the National Science Foundation of the United States (NSF Grant CH-0316806); the American Chemical Society (ACS Grant IRG-98-278-04); and the RhRMA Research Initiative Grant. [0003] Relevant application materials: [0004] This patent application is based on the following provisional application (Provisional Application 60 / 680,326, filed May 12, 2005) filed in the U.S. on May 12, 2005; the provisional application (Provisional Application 60 / 703,079, filed July 28, 2005); the provisional application filed August 9, 2005 (Provisional Application 60 / 706,688, filed August 9, 2005); and the provisional application filed January 4, 2006 (Provisional Application 60 / 756,041, filed January 4 , 2006). The benefit of all such provisional applications is hereby claimed in this patent application. In addition, this application includes all these provisional invention applications. Background ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/04A61K31/70C07G3/00C07G11/00C07H15/00C07H17/00C07H15/24
CPCC07H15/24C07H15/252C07H19/056A61P35/00
Owner THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION