Glycyrrhiza extract for alleviating cardiotoxicity of medicine and application

A technology of licorice extract and cardiotoxicity, applied in drug combination, drug delivery, medical preparations containing active ingredients, etc., can solve the problems of nephrotoxicity and large dosage

Inactive Publication Date: 2008-10-15
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the dosage of dexrazoxane is very large, usually 10 times that of doxorubicin, and it has certain nephrotoxicity
If the combination of dexrazoxane and doxorubicin is used, the economic burden of patients will be increased by 5-10 times

Method used

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  • Glycyrrhiza extract for alleviating cardiotoxicity of medicine and application
  • Glycyrrhiza extract for alleviating cardiotoxicity of medicine and application
  • Glycyrrhiza extract for alleviating cardiotoxicity of medicine and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The licorice medicinal material was extracted twice with 10 times the amount of 70% ethanol, each time for 1.5 hours. After being concentrated to no alcohol, the D101 resin was separated, washed with three column volumes of water, and then washed with 70% ethanol, the effluent was collected, concentrated and dried, that is the total glycyrrhizin extract, with a yield of 10.8%. Taking liquiritin as the reference substance, the total flavonoid content of the extract was determined by UV-spectrophotometry at 25.8%. According to the provisions of "Chinese Pharmacopoeia 2005 Edition Part One", using glycyrrhizic acid as the reference substance, the content of glycyrrhizic acid was determined by HPLC method to be 15.1%.

Embodiment 2

[0014] Radix Glycyrrhiza is extracted twice with 8 times the amount of water by boiling under reflux, each time for 1.5 hours. Combined and cooled, add ethanol to 60%, ethanol precipitation overnight, centrifuge to take the supernatant, concentrate to no alcohol, separate AB-8 resin, wash with three column volumes of water and 20% ethanol in turn, and then wash with 80% ethanol Rinse, collect the effluent, concentrate and dry, that is total glycyrrhizin extract, the yield is 9.2%. Taking liquiritin as the reference substance, the total flavonoid content of the extract was determined by UV-spectrophotometry at 33.4%. According to the provisions of "Chinese Pharmacopoeia 2005 Edition Part One", using glycyrrhizic acid as a reference substance, the content of glycyrrhizic acid was determined by HPLC method to be 25.5%.

Embodiment 3

[0016] Radix Glycyrrhiza is extracted three times with 6 times the amount of water by boiling and refluxing, each time for 1.5 hours. Combined, cooled, concentrated into a clear paste, applied to D101 macroporous adsorption resin, first eluted with three column volumes of water and 20% ethanol, then rinsed with 70% ethanol, collected the effluent, concentrated and dried, that is, the total glycyrrhizin extraction The yield is 8.4%. Taking liquiritin as the reference substance, the total flavonoid content of the extract was determined by UV-spectrophotometry at 68.4%. According to the provisions of "Chinese Pharmacopoeia 2005 Edition Part One", using glycyrrhizic acid as the reference substance, the content of glycyrrhizic acid was determined by HPLC method to be 17.5%.

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Abstract

The invention provides a Radix Glycyrrhizae extract capable of reducing toxicity of drugs to heart. The extract is derived from the root or the rhizome of licorice belonging to the Leguminosae such as Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. and Glycyrrhiza glabra L.; and mainly contains triterpenoid saponins and flavone glycosides as active ingredients, wherein the content of triterpenoid saponins is 10-30%, and the content of flavone glycosides is 25-80%. The in vivo and in vitro tests show that the Radix Glycyrrhizae extract has distinct protective effect on heart injury induced by adriamycin while not weakening the antitumor effect of anthracycline antitumor drugs; and can be used for preventing and reducing the toxicity of anthracycline drugs to heart, so as to improve the therapeutic effect and clinic application range thereof. The Radix Glycyrrhizae extract can be used for preparing medicines for reducing the toxicity of anthracycline drugs to heart.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine extract, which relates to glycosides extracted from the traditional Chinese medicine licorice, mainly including flavonoid glycosides and triterpenoid saponins. Do not weaken the antitumor effect of anthracycline antitumor drugs (such as doxorubicin). Background technique [0002] Since the first anthracycline anticancer drug, Daunorubicin, was isolated in 1957, anthracycline anticancer drugs have become a class of chemotherapy drugs widely used clinically. Doxorubicin (DXR; Adriamycin, ADM) has become an anthracycline anticancer drug since it entered clinical trials in the 1970s. representative drugs. ADM is effective for a variety of tumors, including: hematological tumors, malignant lymphomas, breast cancer, bladder cancer, lung cancer, ovarian cancer, cervical cancer, testicular cancer, head and neck tumors, and bone and soft tissue tumors. ADM is low in price and relatively high in efficacy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K9/48A61K9/20A61K9/10A61K9/16A61K9/08A61P39/02
Inventor 刘雳程翼宇瞿海斌张玲霍杨葛志伟水文波
Owner ZHEJIANG UNIV
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