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Yanghe decoction oral formulations and preparation method thereof

An oral preparation, yang deficiency technology, applied in the field of medicine, can solve the problems of inconvenience in carrying and taking, inaccurate dosage, and inability to commercialize

Inactive Publication Date: 2008-10-15
苏州世林医药技术发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Ancient Yanghe Decoction only had decoctions, which needed to be decocted and taken after purchasing decoction pieces. It was very inconvenient to carry and take it. After research, we made modern oral preparations of traditional Chinese medicine through quantitative control of index components. The product dosage is accurate, the quality is stable, and it is convenient to take. It is suitable for commercialized large-scale production, overcomes the shortcomings of traditional Chinese medicine decoctions such as large dosage, inaccurate dosage, inconvenient carrying and taking, and inability to commercialize, and is convenient for clinical treatment and home use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment one: Yanghe decoction extract (extract and volatile oil) preparation method

[0041] Prescription: 30 parts of rehmannia glutinosa, 6 parts of white mustard seeds, 9 parts of antler gum, 3 parts of cinnamon, 2 parts of ginger charcoal, 2 parts of ephedra, 3 parts of licorice

[0042] Preparation method: cleanly select the prescription medicinal materials, weigh each medicinal material according to the prescription amount, add 8 to 12 times the amount of water to soak for 2-10 hours, heat and boil for 2-3 times, combine the extracts, collect the volatile oil; water extraction The liquid was left to stand for 12-48 hours, filtered to get the supernatant, and concentrated under reduced pressure to obtain a medicinal extract of about 17.5 g of water extract and about 0.2 g of volatile oil.

Embodiment 2

[0043] Example 2: Preparation method of oral solid preparation of Yanghe Decoction

[0044] (1) Preparation of Yanghe Decoction Granules

[0045] prescription:

[0046] Yanghe Decoction Extract 10-90%

[0047] Starch 5.0-70%

[0048]Dextrin 2.0-20%

[0049] Xylitol 5.0-20%

[0050] Methyl sorbate 0.001-2.0%

[0051] Preferred Prescription:

[0052] Yanghe Decoction Extract 17.7g

[0053] Starch 8.0g

[0054] Dextrin 8.0g

[0055] Xylitol 4.0g

[0056] Methyl sorbate 0.002g

[0057] Preparation method: prepare the Chaiyanghe decoction extract according to the method in Example 1, add the prescribed amount of auxiliary materials to make granules according to the conventional method, dissolve the volatile oil with an appropriate amount of ethanol, spray evenly on the granules, dry at low temperature, and pack. 10g per bag.

[0058] (2) Preparation of Yanghe Decoction Effervescent Tablets

[0059] Prescription: Yanghe Decoction Extract 17.7

[0060] Starch 5g...

Embodiment 3

[0096] Example 3: Preparation method of Yanghe Decoction oral liquid preparation

[0097] (1) Preparation of oral liquid

[0098] Prescription: Yanghe Decoction Extract 5-80%

[0099] Sucrose 5.0-50%

[0100] Sodium cyclamate 5.0-40%

[0101] Methyl sorbate 0.001-2%

[0102] Span 20 5.0-40%

[0103] Distilled water 10-90%.

[0104] Preferred Prescription:

[0105] Yanghe Decoction Extract 17.7g

[0106] Sucrose 5.0g

[0107] Sodium cyclamate 1.5g

[0108] Span 20 2.5g

[0109] Methyl sorbate 0.02g

[0110] Make up to 60ml with distilled water.

[0111] Preparation method: prepare the Yanghe decoction extract according to the method in Example 1, add the excipients of the prescription and distilled water, then ultrafilter through an ultrafilter, fill the ultrafiltrate, and sterilize to obtain the product.

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PUM

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Abstract

The invention relates to a Yang-Activating Decoction medicine oral preparation prepared from seven Chinese traditional medicines including prepared rhizome of rehmannia, and a preparation method thereof. The oral preparation is prepared from mixed extracts (extract or dried powder and volatile oil) of prepared rhizome of rehmannia, white mustard seed, carrageenin, cinnamon, dry ginger charcoal, ephedra, and licorice root, and pharmaceutically acceptable carrier or excipient as ground substance in the conventional preparation method. The oral preparation can be mainly used for treating dorsal furuncle due to yang insufficiency, blood deficiency, accumulation of pathogenic cold and phlegm stagnation. The long term clinical application of the prescription indicates that the oral preparation has good curative effect on dorsal furuncle due to yang insufficiency, accumulation of pathogenic cold, menoxenia due to blood deficiency, and phlegm dampness and stagnation in joint and meridian.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a drug oral preparation and a preparation method thereof for mainly treating yang deficiency and blood weakness, cold phlegm and phlegm stagnation, and particularly relates to a drug whose active ingredient is the extract of a traditional Chinese medicine formula of Yanghe Decoction Oral preparations. Background technique [0002] "Yanghe Decoction" was created by Wang Weide in the Qing Dynasty in "Surgical Syndrome and Treatment of Quansheng Ji". , white mustard seed, antler gum, cinnamon, ginger charcoal, ephedra, and licorice, has the effects of warming yang and nourishing blood, dispelling cold and clearing stagnation. The long-term clinical application of this prescription has shown that it has a good curative effect on yin gangrene caused by yang deficiency and cold coagulation, nutrient blood deficiency stagnation, phlegm dampness stagnation in joints, meridians, etc., and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/48A61K9/20A61K9/16A61K9/10A61K47/38A61K47/34A61K47/32A61P7/06A61P1/14A61K47/10
Inventor 张文芳
Owner 苏州世林医药技术发展有限公司
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