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Inhibition of bacterial deposition on oral surfaces

A technology of oral cavity and surfactant, applied in the field of oral composition, which inhibits the deposition of bacteria on the surface of the oral cavity

Inactive Publication Date: 2008-10-15
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] These conventional compositions may be effective

Method used

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  • Inhibition of bacterial deposition on oral surfaces
  • Inhibition of bacterial deposition on oral surfaces
  • Inhibition of bacterial deposition on oral surfaces

Examples

Experimental program
Comparison scheme
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Embodiment 1

Embodiment 2

Embodiment 3

[0046] The gargle formula of Example 1 was tested in human clinical trials to inhibit the percentage of dental plaque. This was compared to a formulation of similar composition but lacking betaine and phenolic compounds. For the gargle of Example 1, 36% plaque inhibition was found. For the comparison rinse without betaine and with phenolic compounds, 21% plaque inhibition was found.

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Abstract

The present invention is directed to an oral composition that contains an amphoteric surfactant and an homo- or copolymer comprising an ethylenic monomer and related methods. The ethylenic monomer includes a phosphonate group. The monomer may be represented by the structure of Formula (I), wherein one of A and A' is a hydrogen atom and the other is selected from a hydrogen atom or a group -(X)nRm; wherein n is i\selected from 0 or 1; provided that when n is 0, m is 1, and when n is 1, m is an integer of 1 to 3; X is selected from an oxygen atom, a sulfur atom, a nitrogen atom, a phosphorous atom, and silicon atom; R is independently a hyuderogen atom or an arganic radical; L is selected from a bond and a linking group; M and M' are independently selected from a hydrogen atom, an alkali metal, and an ammonium ion, or together form an alkaline earth metal or other divalent element; and p is 1 or 2, provided that when L is a bond, p is 1.

Description

Background of the invention [0001] Many diseases are linked to the action of bacteria in the mouth. For example, infected inflammation of the gums and alveolar bone, ie, gingivitis, is caused by toxins and other substances secreted by plaque-forming bacteria, including Actinomyces viscosus. [0002] In addition, dental plaque provides a site for tartar or calculus to form. Periodontitis can occur when unremoved plaque hardens within tartar (calculus), which can involve the periodontal ligament. As plaque and calculus continue to build up, the gums begin to recede, leading to ongoing infections and, potentially, tooth loss. To prevent or treat these diseases, antimicrobial agents have been incorporated into oral care compositions such as toothpastes and mouthwashes. A variety of materials have been proposed for the control of plaque, tartar, calculus, gingivitis and related diseases. [0003] These conventional compositions may be effective. However, due to the varying med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/896A61Q11/00
CPCA61K8/44A61K8/81A61Q11/00
Inventor A·加法T·J·博伊德
Owner COLGATE PALMOLIVE CO