Bitong capsule and preparation thereof

A technology of capsules and Bitong, which is applied in the field of Bitong Capsules and its preparation, which can solve the problems that active ingredients are difficult to function and inconvenient to take, and achieve the effects of improving bioavailability, taking convenience, and reducing odor

Inactive Publication Date: 2008-11-12
沈阳双鼎制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The standard prescription "Bitong Wan" issued by the ministry is a pill formulated according to the understanding of the cause and pathogenesis of rhinitis in traditional Chinese medicine and the basic theory of traditional Chinese medicine. inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Bitong Capsules and its preparation method are as follows: 408g of fried cocklebur, 408g of peppermint, 272g of Angelica dahurica, 136g of Magnolia magnolia, 136g of Goose Bubiograss, soaked in 18 times the amount of water for 2 hours, steam distilled for 5 hours to extract volatile oil, set aside, and collect Distilled aqueous solution; decoct dregs, 408g of Scutellaria baicalensis and 136g of licorice twice, add 12 times the amount of water for 3 hours for the first time, add 10 times the amount of water for 2 hours, combine the decoction, filter , the filtrate was combined with the distilled aqueous solution, concentrated at 60°C to a relative density of 1.06-1.10, let cool, added ethanol to make the alcohol content reach 70%, left for 24 hours, filtered, concentrated at 60°C to a relative density of 1.30-1.34, and reduced pressure Dried at 60°C and crushed to obtain dry extract powder; inclusion of volatile oil with β-cyclodextrin, dried at 30°C under reduced pressur...

Embodiment 2

[0020] Bitong Capsule and its preparation method, soak 371g of fried cocklebur, 371g of peppermint, 247g of Angelica dahurica, 124g of magnolia, 124g of geese not eating grass, add 15 times the amount of water for 1 hour, steam distillation for 4 hours to extract volatile oil, set aside, collect and distill Afterwards, the aqueous solution: decoct the dregs, 371g of Scutellaria baicalensis, and 124g of licorice twice, add 10 times the amount of water for 2 hours for the first time, and decoct for 1.5 hours for the second time with 8 times the amount of water, combine the decoction, filter, Combine the filtrate with the distilled aqueous solution, concentrate at 60°C to a relative density of 1.03-1.05, let it cool, add ethanol to make the alcohol content reach 65%, leave it for 24 hours, filter, concentrate at 60°C to a relative density of 1.30-1.35, and decompress at 60 Dry at ℃ and pulverize to obtain dry extract powder; wrap the volatile oil with β-cyclodextrin, dry at 30°C u...

Embodiment 3

[0022] Bitong Capsule and its preparation method, 450g of fried cocklebur, 450g of peppermint, 300g of Angelica dahurica, 150g of magnolia, 150g of goose herb plus 20 times the amount of water, soaked for 3 hours, steam distilled for 6 hours to extract volatile oil, set aside, collect and distill Afterwards, aqueous solution; decoct medicinal dregs, 450 g of Scutellaria baicalensis, and 150 g of licorice twice, add 15 times the amount of water to decoct for 2.5 hours for the first time, and decoct for 1.5 hours with 12 times the amount of water for the second time, combine the decoction, filter, Combine the filtrate with the distilled aqueous solution, concentrate at 60°C to a relative density of 1.02-1.05, let it cool, add ethanol to make the alcohol content reach 80%, leave it for 24 hours, filter, concentrate at 60°C to a relative density of 1.29-1.32, and decompress for 60 Dry at ℃ and pulverize to obtain dry extract powder; wrap the volatile oil with β-cyclodextrin, dry at...

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Abstract

The invention relates to a nasographic capsule. The traditional Chinese medicinal materials for preparing the nasographic capsule are: 300 to 450 grams of fried fructus xanthil, 100 to 150 grams of lily magnolia, 200 to 300 grams of angelicas dahurica, 100 to 150 grams of centipede, 300 to 450 grams of peppermint, 300 to 450 grams of radix scutellariae and 100 to 150 grams of liquorice. The auxiliary material for preparing the nasographic capsule comprises at least one of the followings: 3 to 10 percent of methylcellulose, 5 to 15 percent of ethylcellulose, 3 to 6 percent of sodium carboxymethyl cellulose, adequate hydroxypropyl methylcellulose, 3 to 20 percent of microcrystalline cellulose, 5 to 20 percent of dextrin, 3 to 15 percent of calcium hydrophosphate, 5 to 20 percent of starch, 0.25 to 2.0 percent of magnesium stearate, 0.5 to 2.0 percent of stearin, 1 to 3 percent of calcium phosphate, 3 to 6 percent of talcum powder, 1 to 3 percent of colloidal silica and adequate ethanol, wherein, the percentage of the auxiliary material is the weight percentage of the made medicine. The invention makes the prior oral pill into the capsule after technical study, thereby the nasographic capsule not only gives play to the function of the prior prescription medicinal odour but also improves the bioavailability; and the nasographic capsule has the characteristics that: the nasographic capsule is convenient in taking, reduces the peculiar smell for directly taking the pill, and is suitable for wide medicated crowd, etc.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a Bitong capsule and a preparation method thereof. Background technique [0002] Though rhinitis is not serious disease, the sickness rate of rhinitis is higher, is a kind of common disease, frequently-occurring disease. Due to the close relationship between the anatomical structure and physiological functions of the ear, nose, and throat, rhinitis can affect other organs, causing complications such as otitis media, pharyngitis, laryngitis, pneumonia, tracheitis, and bronchitis, seriously affecting the quality of life of patients. In addition, its prevalence rate has continued to increase in recent years, so it has attracted great attention from the global pharmaceutical industry, and the market size has also expanded accordingly. [0003] At present, the treatment of rhinitis is mainly divided into traditional Chinese medicine and western medicine. Western medicine tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/575A61K9/48A61K47/38A61P11/02
Inventor 马占芝李志强詹君王学东李桂艳
Owner 沈阳双鼎制药有限公司
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