Peptide feedstuff additive for regulating immunity function of sea water fish

Abstract

The invention discloses peptide feed additive used to modulate the immune functions of seawater fish. The peptide feed additive consists of three or more than three types in peptide which is produced by enzymatic hydrolysis of cod fish, skin and internal organs with the molecular weight ranges respectively 100Da to 500Da, 500Da to 1500Da, 1500Da to 3000Da, 3000Da to 5000Da, and 5000Da to 8000Da. 1 percent to 5 percent of immune modulator of the invention is added into feed, which can obviously improve the level of IgM and muramidase in the serum of the seawater fish; the immune modulator of the invention can also improve the liver SOD level of the cultivated fish, thereby improving the oxidation resistant capability of the cultivated fish. The immune modulating peptide feed additive of the invention can also obviously improve the daily weight gain of the fish and reduce the liver index. The peptide feed additive used to modulate the immune functions of the seawater fish is safe without public harm, and the fish cultivated by the additive meet the green food sanitation requirements.

Description

technical field [0001] The invention relates to a feed additive, in particular to a peptide feed additive for regulating the immune function of seawater fish. Background technique [0002] With the rapid development of seawater fish cage culture, the probability of fish infection is greatly increased due to reasons such as excessive breeding density, increased feeding frequency, and deterioration of water quality, and it is becoming more and more serious, which has caused serious damage to the breeding industry. Huge economic loss. Antibiotics are mostly used in the prevention and control of diseases of cultured marine fish. With the extensive use and long-term use of antibiotics, not only the control effect is poor, but also the following adverse consequences will be caused: such as the production of bacterial drug-resistant strains, the imbalance of normal microbial populations in water bodies, and the damage of animal viscera (Weston, 1996). In addition, due to the non-...

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Problems solved by technology

Therefore, peptides have the potential to be developed as immunomodulators for aquatic animals. At present, there are only reports on the use of mixed peptide components produced by microbial fermentation as immunomodulators for aquatic animals. Howev

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