Method for preparing sevoflurane

A technology of sevoflurane and fluoride, which is applied in the field of preparation of sevoflurane, can solve problems such as harsh requirements and difficult separation, and achieve the effects of increasing safety, reducing production costs and improving utilization rate

Active Publication Date: 2012-04-25
JIANGSU HENGRUI MEDICINE CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods all directly use highly toxic hydrogen fluoride gas, and hydrogen fluoride gas has certain corrosiveness, so the method has strict requirements on production equipment, and in addition, the product also contains substances that are difficult to separate

Method used

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  • Method for preparing sevoflurane
  • Method for preparing sevoflurane

Examples

Experimental program
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Effect test

Embodiment 1

[0011] Example 1 (CF 3 ) 2 CHOCH 2 OCH 3 Synthesis

[0012] In a 500ml flask, add 168 grams of hexafluoroisopropanol, 100 grams of CH 2 (OCH 3 ) 2 and 2 grams of p-toluenesulfonic acid, stirred at room temperature for 24 hours, added 100ml of water, added 10% NaOH to adjust to PH=9, separated the organic layer, washed the organic layer with water, and distilled it at atmospheric pressure to recover the distillate at 76-78°C. The product was obtained to obtain 82 grams (CF 3 ) 2 CHOCH 2 OCH 3 (GC purity 98.3%).

Embodiment 2

[0013] Example 2 Synthesis of Sevoflurane

[0014] Add 21.2 grams (CF 3 ) 2 CHOCH 2 OCH 3 (GC purity 98.3%), 100 gram KF and 100 gram fuming sulfuric acid, gradually warming up to 50 ℃ in 8 hours, collect the steam that reaction produces with water trap, after the gained organic layer is washed with water, get 18 gram organic matter . GC analysis showed that the obtained organic matter contained 90.0% sevoflurane (yield 80%). The resulting organic matter was fractionally distilled, and the 50-54°C fraction was collected to obtain 14.5 g of sevoflurane product (99.6% purity by GC).

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Abstract

The invention relates to a method for preparing sevoflurane [fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether], which comprises the following steps: reacting hexafluoroisopropanol with dimethoxymethane in the presence of a catalyst to obtain methoxymethylene hexafluoroisopropyl ether, and reacting methoxymethylene hexafluoroisopropyl ether with a fluoride in the presence of a strong acid to obtain the sevoflurane.

Description

technical field [0001] The invention relates to a preparation method of fluoride, in particular to a preparation method of sevoflurane. Background technique [0002] Sevoflurane [fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether] is an inhalation anesthetic. The known preparation methods of sevoflurane include: heating concentrated sulfuric acid, A mixture of hydrogen fluoride, paraformaldehyde and hexafluoroisopropanol, and then capture the resulting gas (US 4,469,898); add trioxane to hydrogen fluoride, and then add HFIPA (JP-T-7-502307); Sulfuric acid, hydrogen fluoride and (CF 3 ) 2 CHOCH 2 OCH 3 The mixture is heated together, and then traps the generated gas (CN1074759C); and other methods similar to the above methods. In addition, there is another method of fluorinating chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether to obtain sevoflurane. However, these methods all directly use highly toxic hydrogen fluoride gas, and hydrogen fluoride gas has cert...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C43/12C07C41/14
Inventor 孙飘扬蒋勇陈永江
Owner JIANGSU HENGRUI MEDICINE CO LTD
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