Reagent for assaying antiphospholipid antibody and reagent for assaying anti-treponema pallidum antibody

An anti-phospholipid antibody, Treponema pallidum technology, applied in biological tests, measuring devices, material testing products, etc., can solve problems such as serum interference and inability to obtain measurement results

Active Publication Date: 2012-08-22
SEKISUI MEDICAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, although such sensitizers are excellent in promoting antigen-antibody reactions, accurate measurement results cannot be obtained with some samples.
Specifically, when the specimen is serum, by changing the components contained in the serum, a phenomenon called serum interference that adversely affects the measurement occurs, and accurate measurement results cannot be obtained.

Method used

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  • Reagent for assaying antiphospholipid antibody and reagent for assaying anti-treponema pallidum antibody
  • Reagent for assaying antiphospholipid antibody and reagent for assaying anti-treponema pallidum antibody
  • Reagent for assaying antiphospholipid antibody and reagent for assaying anti-treponema pallidum antibody

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0096] (1-1) In the preparation of the first reagent, 0.70% by weight of Lipitor D03 neutralized with NaOH was added to a phosphate buffer solution containing 1% bovine serum albumin (LotA: manufactured by Serologicals Co., Ltd.) (manufactured by NOF Corporation, molecular weight: 1,000,000), except that the first reagent was prepared, and an antiphospholipid antibody measurement reagent was prepared in the same manner as in Example 1.

Embodiment 3

[0098] (1-1) In the preparation of the first reagent, 0.45% by weight of Lipitor D05 neutralized with NaOH was added to a phosphate buffer solution containing 1% bovine serum albumin (LotA: manufactured by Serologicals Co., Ltd.) (manufactured by NOF Corporation, molecular weight: 1,000,000), except that the first reagent was prepared, and an antiphospholipid antibody measurement reagent was prepared in the same manner as in Example 1.

Embodiment 4

[0116] (1-1) In the preparation of the first reagent, in the phosphate buffer containing 1% bovine serum albumin (LotB), 0.66% by weight of Lipitor D03 (NOF Co., Ltd.) neutralized with NaOH was added. Preparation), except that, in the same manner as in Example 1, an antiphospholipid antibody assay reagent was prepared.

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Abstract

The invention aims to provide a reagent for assaying an antiphospholipid antibody which is excellent in long-term storage stability and capable of diagnosing syphilis infection or the like and a reagent for assaying an anti-Treponema pallidum antibody which is capable of diagnosing syphilis infection with high accuracy by preventing the occurrence of serum interference. The invention is directed to the reagent for assaying an antiphospholipid antibody to be used for diagnosing syphilis infection comprising an insoluble carrier carrying an antiphospholipid antigen and a copolymer with a segment derived from 2-methacryloyloxyethyl phosphorylcholine and a segment derived from a hydrophilic monomer.

Description

technical field [0001] The present invention relates to an antiphospholipid antibody assay reagent capable of accurately diagnosing syphilis infection and having excellent long-term storage stability, and an anti-Treponema pallidum capable of accurately diagnosing syphilis infection by preventing the occurrence of serum interference Antibody assay reagents. Background technique [0002] Treponema pallidum, the causative agent of syphilis, upon infecting an organism, produces antibodies against the pathogen and antibodies reactive with phospholipids. The antiphospholipid antibody assay reagent is a reagent for determining syphilis infection by measuring the presence or absence of antibodies reactive with phospholipids in blood. [0003] Conventionally, in antiphospholipid measurement, methods such as the RPR card test using a judgment board have been performed, but in recent years, reagents (automated reagents) that can be applied to automatic biochemical analyzers are being...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/531G01N33/545G01N33/571G01N33/92
Inventor 赤峰隆之大田哲也李艳
Owner SEKISUI MEDICAL CO LTD
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