Chinese medicine formulations for treating hepatitis B and preparation method thereof

A technology for traditional Chinese medicine preparations and hepatitis B, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery, etc., can solve the problems of long disintegration time in vivo, poor stability, and loss of active ingredients of drugs.

Active Publication Date: 2009-01-14
陕西东泰制药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Ministry-issued standard "Prescriptions of Traditional Chinese Medicine" Volume 19 WS 3 - "Yigan Ling Wan" under item B-3524-98 is a traditional Chinese medicine pill for treating hepatitis B. Its preparation process is complicated, and the drying time is as long as more than ten hours. The active ingredients of the drug are seriously lost; , and the stability is poor, the clinical efficacy is difficult to guarantee; with the rising incidence of the disease, it is far from meeting the clinical needs

Method used

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  • Chinese medicine formulations for treating hepatitis B and preparation method thereof
  • Chinese medicine formulations for treating hepatitis B and preparation method thereof
  • Chinese medicine formulations for treating hepatitis B and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Formula ratio:

[0096] 83.5 parts of rhubarb, 250 parts of white peony, 333.25 parts of capillary, 166.5 parts of Bupleurum

[0097] Guanzhong 333.25 parts Ginseng 83.5 parts Astragalus 83.5 parts Licorice 166.5 parts

[0098] The preparation method of the capsules of the present invention: take ginseng, rhubarb, and white peony root and grind them into fine powders respectively, pass through a 100-mesh sieve, and set aside; add water for three times to decoct astragalus, bupleurum, capillary, licorice, and rhubarb, and add water for the first time. Double the amount, decoct for 3 hours, add 10 times the amount of water for the second time, decoct for 2 hours, add 10 times the amount of water for the third time, decoct for 1 hour, filter respectively, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.10 ( 80 ℃ of clear ointment), spray-drying, the obtained medicine fine powder mixes with above-mentioned fine powder, packs into ca...

Embodiment 2

[0100] Formula ratio:

[0101] 83.5 parts of rhubarb, 250 parts of white peony, 333.25 parts of capillary, 166.5 parts of Bupleurum

[0102] Guanzhong 333.25 parts Ginseng 83.5 parts Astragalus 83.5 parts Licorice 166.5 parts

[0103] The preparation method of the granules of the present invention is as follows: take ginseng, rhubarb, and white peony root, grind them into fine powder respectively, pass through a 100-mesh sieve, and set aside; 12 times the amount, decoct for 3 hours, add 10 times the amount of water for the second time, decoct for 2 hours, add 10 times the amount of water for the third time, decoct for 1 hour, filter separately, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.10 (measured at 80° C.), spray-dry, and mix the obtained drug fine powder with the above-mentioned fine powder and an appropriate amount of powdered sugar or dextrin, granulate, dry, granulate, and pack into bags to obtain the granules of the prese...

Embodiment 3

[0105] Formula ratio:

[0106] 83.5 parts of rhubarb, 250 parts of white peony, 333.25 parts of capillary, 166.5 parts of Bupleurum

[0107] Guanzhong 333.25 parts Ginseng 83.5 parts Astragalus 83.5 parts Licorice 166.5 parts

[0108] The preparation method of the tablet of the present invention is as follows: take ginseng, rhubarb, and white peony root and grind them into fine powders, pass through a 100-mesh sieve, and set aside; add water to boil three times for astragalus, bupleurum, capillary, licorice, and rhubarb, and add water for the first time. 12 times the amount, decoct for 3 hours, add 10 times the amount of water for the second time, decoct for 2 hours, add 10 times the amount of water for the third time, decoct for 1 hour, filter separately, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.10 (measured at 80°C), spray-dry, and mix the obtained drug fine powder with the above-mentioned fine powder and an appropriate amount...

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Abstract

The invention relates to a Chinese herb preparation for remedying hepatitis b and a preparation method thereof. The Chinese herb preparation is formed by rhubarb, paeonia lactiflora pallas, herba artemisiae capillaries, radix bupleuri, cyrtomium fortunei, ginseng, milk veteh and liquorice, which has the effects of clearing heat and toxic material, smoothing liver and strengthening spleen. The invention is mainly used to remedy the stasis of liver energy, the besiegment of spleen by dampness and hepatitis b. Compared with the prior technology, the invention has the advantages of simple preparation technology, active ingredient of high content, easy quality control, exact dosage, high bioavailability, notable curative effect and good stability.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating hepatitis B and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. technical background [0002] Hepatitis B is a common and frequently-occurring disease in internal medicine. The main symptoms and signs are fatigue, loss of appetite, pain in the liver area, hepatosplenomegaly, or jaundice. Due to the low conversion rate of clinical treatment, it is often protracted and difficult to heal, and some patients may develop post-hepatitic cirrhosis or even liver cancer. my country is a high-incidence area of ​​hepatitis, with an average HBV infection rate of 10%. Moreover, in recent years, due to the acceleration of people's work rhythm and the increasing development of the catering industry, relatively speaking, the imperfect food hygiene and disinfection measures make the infection rate of hepatitis B virus still on the ri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/00A61K9/48A61P31/16A61P31/20
Inventor 罗川
Owner 陕西东泰制药有限公司
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