Slowly released type antibiotic medical catheter and preparation method thereof

A medical catheter and slow-release technology, applied in catheters and other directions, to achieve the effect of high silver loading, saving medical resources and good safety

Inactive Publication Date: 2009-02-11
HUADONG HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are products on the market (products of Shanghai Runhe Nano Material Technology Co., Ltd.), but so far there has been no repo

Method used

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  • Slowly released type antibiotic medical catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example 1. Preparation of PU central vein antibacterial medical catheter

[0031] 1. Preparation of PU antibacterial plastic masterbatch

[0032] Blend 1 kg of silver-loaded zirconium phosphate antibacterial powder with 4% silver content and 3 kg of barium sulfate powder, then add it to 6 kg of PU resin, blend and extrude, to obtain 10% silver-containing inorganic antibacterial powder PU antibacterial plastic masterbatch.

[0033] 2. Preparation of central venous catheter

[0034] Blend 5 kilograms of PU antibacterial plastic masterbatch and 45 kilograms of PU raw materials, and prepare the central venous antibacterial medical catheter through the related tube making process according to the routine.

Example Embodiment

[0035] Example 2. Preparation of antibacterial urinary catheter

[0036] Blend 1 kilogram of zirconium phosphate containing silver antibacterial powder with 6% silver loading and 99 kilograms of PVC powder, mix them thoroughly, and obtain an antibacterial urinary catheter through a conventional catheter production process.

Example Embodiment

[0037] Example 3. Preparation of PVC antibacterial urinary catheter

[0038] 1. Preparation of PVC antibacterial masterbatch:

[0039] One kilogram of zirconium phosphate containing silver antibacterial powder with 10% silver loading and 4 kilograms of PVC particles are blended, and an antibacterial PVC masterbatch containing 20% ​​silver-based inorganic antibacterial powder is obtained through a twin-screw extrusion process.

[0040] 2. Preparation of antibacterial urinary catheter: 5 kg of antibacterial PVC masterbatch and 95 kg of PVC slices are blended, and an antibacterial urinary catheter is prepared through a conventional catheter production process.

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PUM

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Abstract

The invention relates to the technical field of medical apparatus and instruments, which discloses a sustained release type antibacterial medical catheter and a preparation method thereof. A silver inorganic antimicrobial is characterized by high content of silver, safety and the like, and the silver inorganic antimicrobial which adopts zirconium phosphate as a carrier is selected and mixed into catheter material to prepare the sustained release type antibacterial medical catheter that is most widely applied to clinic, such as an antibacterial catheter, an antibacterial central venous catheter, an antibacterial trachea cannula and the like. The catheter has high use safety, wide antibacterial spectrum, good antibacterial effects, antimicrobial constituent sustained release and long duration of antibacterial effects, and can reduce the frequency of replacing medical catheters so as to have safe and convenient clinical use, effectively reduce nosocomial infections related to catheters due to the use of the medical catheters, greatly reduce medical expenses related to anti-infection, and the like, and save medical resources.

Description

technical field [0001] The invention relates to the technical field of medical devices, and relates to a slow-release antibacterial medical catheter and a preparation method thereof. Background technique [0002] Medical catheters are widely used medical devices in clinical medical work. They are made of medical plastic catheter materials with or without plastic fillers. Medical catheters usually need to be implanted into the human body for invasive diagnosis and treatment, such as urinary catheters, central venous catheters, and endotracheal intubations. Medical catheters have become an important factor in concurrent catheter-related nosocomial infections, especially in patients with immunodeficiency or diabetes, infants, and the elderly, who are more prone to catheter-related infections. For example, urinary tract infection accounts for about 40% of nosocomial infections and is one of the most common nosocomial infections, among which about 50% are related to catheters. ...

Claims

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Application Information

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IPC IPC(8): A61L29/06A61L29/16
Inventor 瞿介明陶志清
Owner HUADONG HOSPITAL
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