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Use of polymeric materials with other substances for improved performance

A technology of polymers, composite materials, used in the field of using polymer materials with other substances for improving properties

Inactive Publication Date: 2009-06-10
吉利西斯公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, none of these drugs and materials are sufficiently safe for users to provide a satisfactory means of obesity management or a means of inducing weight loss

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Observation of gastric contents in rats after administration of polymer materials

[0098] Wistar rats with the characteristics listed in Table 1 were each housed in Velaz T4 cages under conventional laboratory conditions. The room temperature is 20-24° C. and the relative humidity is 30-70%. Fluorescent lights provide approximately 12 hours of light per day. Feed and water containers were changed and sanitized at least once a week. Lignocel (Velaz Ltd., Czech Republic) was used as bedding.

[0099] Table 1. Wistar rats used in the test system

[0100] species and strains Wistar rat quality conventional age at delivery 6-9 weeks weight at time of administration 200-300 grams Number of groups 3 Number of rats per group 2 total number of animals 6

[0101] Animals were fed ad libitum with standard pelleted rodent chow (NOE H4, Racio Breclav, Czech Republic) of monitored quality (minimum 2 analyzes per year for poss...

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Abstract

Methods of enabling or improving the ability of a hydrogel to swell in the stomach of an animal and / or increasing the amount of time said hydrogel remains swollen in the stomach are described herein. In one embodiment, a polymer is administered in combination with one or more pH modifying agents which raise and maintain the pH of the micro environment of the polymer and / or the stomach in order inducing swelling in the polymer. The polymer can be a homopolymer, a copolymer, or a polymer blend or composite. In one embodiment, the polymer is a superabsorbent polymer (''SAP''). The polymers can also be administered with one or more active agents, such as appetite suppressants. The pH modifying agent and / or the active agent can be administered simultaneously with the polymer in the same dosage form, simultaneously with the polymer in separate dosage forms, or sequentially. The compositions are formulated for oral administration. The formulation can include drugs for delivery to the stomach, such as antibiotics, or the hydrogel can be used as filler, for example, for obesity control. The formulation an also be used to enhance gastric retention, for example, for controlled drug delivery. Methods of delivering a drug are also described herein, along with medicaments for carrying out the methods of the present invention.

Description

[0001] related application [0002] This application claims the benefit of priority to US Provisional Patent Application Serial Nos. 60 / 786,615, filed March 28, 2006, and 60 / 787,396, filed March 30, 2006, both of which are incorporated herein by reference in their entirety. field of invention [0003] The present invention is the use of pH dependent polymers to induce weight loss and treat gastrointestinal disorders via mechanistic and physiological means by eliciting the proper gastric pH and by further using the polymer in combination with other pharmacological and surgical means to induce weight loss method field. Background of the invention [0004] Public health efforts and existing anti-obesity drugs have not yet controlled the growing epidemic of obesity. This disorder is increasingly prevalent in industrialized countries due to food abundance and reduced activity levels that accompany population movements from rural to urban areas. Obesity is loosely defined as exc...

Claims

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Application Information

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IPC IPC(8): A61K9/14
Inventor E·埃伦科E·S·伦Y·佐哈
Owner 吉利西斯公司
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