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Medicament composition for treating cardiac and cerebral vascular disease

A technology of cardiovascular and cerebrovascular diseases and compositions, which is applied in the direction of cardiovascular system diseases, drug combinations, and pharmaceutical formulations, and can solve problems such as large and unsafe drug dosages

Inactive Publication Date: 2009-07-08
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to combine two drugs that act on different targets and can significantly reduce the infarct area of ​​the brain tissue and significantly reduce the behavioral disorder caused by brain tissue necrosis. Since the drug interaction is a synergistic interaction, And it is stronger than the additive effect of individual drugs; it solves the problem of unsafe drug dosage; it makes the drug curative effect faster and stronger
The purpose of the present invention is to address the above-mentioned deficiencies in the prior art, and to provide a kind of pharmaceutical composition for the treatment of ischemic cerebrovascular disease, mainly in order to solve the problem of using ginsenoside or safflower yellow alone as a method for treating ischemic cerebrovascular disease. Various problems in vascular diseases, specific receptors manipulate Ca 2+ Combined use of channel blocker ginsenoside Rd and platelet activating factor receptor antagonist safflower yellow

Method used

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  • Medicament composition for treating cardiac and cerebral vascular disease
  • Medicament composition for treating cardiac and cerebral vascular disease
  • Medicament composition for treating cardiac and cerebral vascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 Preparation of injection

[0055] 1. Prescription:

[0056]

[0057] 2. Preparation:

[0058] Take ginsenoside-Rd, safflower yellow A, sodium chloride, 1,2-propanediol; dissolve sodium chloride to 500ml of 20% propylene glycol aqueous solution, add ginsenoside-Rd, safflower yellow A at 60~70℃ Stir on a water bath until it is completely dissolved, cool to room temperature, add the remaining amount of water for injection to 1000ml, mix well and filter with a 0.22μm filter membrane. The filtrate is bottled, filled, sealed, and sterilized, ready to go.

Embodiment 2

[0059] Example 2 Preparation of dropping pills

[0060] 1. Prescription:

[0061]

[0062] 2. Preparation:

[0063] Take polyethylene glycol 6000, place it in a container, heat it to 70-80℃, when it is all melted, and when the temperature drops to about 50℃, add ginsenoside-Rd and safflower yellow A to melt, and the temperature is controlled at 40 -50℃, pour it into the dropping pill machine, drip into the simethicone, and make the drop pill, ready to be obtained.

Embodiment 3

[0064] Example 3 Preparation of sublingual lozenges

[0065] 1. Prescription:

[0066]

[0067] 2. Take ginsenoside-Rd, safflower yellow A, hydroxypropyl methylcellulose (E-50), hydroxypropyl methylcellulose (E-4M), hydroxypropyl cellulose, micronized silica gel, hard Magnesium fatty acid is mixed uniformly by equal addition method, and directly pressed into sublingual lozenge to obtain it.

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PUM

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Abstract

The invention belongs to the technical field of medicine and discloses a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases. The pharmaceutical composition is prepared by ginsenoside and carithamine as main ingredients and can be prepared into pharmaceutically or clinically acceptable dosage forms. The pharmaceutical composition has functions of expanding blood vessels of brain, reducing cerebral vascular resistance, increasing cerebral blood flow, obviously minimizing infarct area of brain tissues, obviously lightening behavior disorders caused by brain tissue necrosis, and the like, and can be used for preparing medicaments for treating diseases such as cerebral circulation insufficiency, cerebral thrombosis, cerebral embolism, brain blood vessels spasm, brain insufficiency, senile dementia, Parkinsonism, cerebral apoplexy, hypertension, hyperlipemia, arteriosclerosis, coronary heart disease, angina pectoris, miocardial infarction, etc.

Description

Technical field: [0001] The invention is a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, which is made of ginsenoside and safflower yellow pigment, and belongs to the technical field of medicines. Background technique: [0002] Cerebral thrombosis, cerebral arteriosclerosis, coronary heart disease, angina pectoris and other cardiovascular and cerebrovascular diseases seriously threaten human life and health. According to epidemiological investigations, the incidence and death of cardiovascular and cerebrovascular diseases in rural or urban areas in the past 50 years The rates of cardiovascular and cerebrovascular diseases are on the rise. The incidence of cardiovascular and cerebrovascular diseases worldwide is between 140 and 200 per 100,000 people, and the average mortality rate is 100 per 100,000. The first of these diseases. Therefore, the research of therapeutic drugs is very necessary, and it is also a hot spot of research at home and ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/351A61P9/10A61P9/08A61P9/00
Inventor 张观福杜健
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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