Small peptide for inhibiting solid tumor and leukaemia cancer cell growth and use thereof

Abstract

The invention provides a short peptide for inhibiting the solid tumor and the growth of the cancer cells of leukemia. The amino acid main sequence of the short peptide fragment, the analogue, the derivative and the variant of the short peptide has the sameness being equal to or more than 70 percent of the amino acid main sequence of the short peptide and has the similarity being equal to or more than 90 percent of the amino acid main sequence of the short peptide; and the short peptide, the nucleotide, the short peptide fragment, the short peptide analogue, the short peptide derivative and the short peptide variant are used for preparing drugs for curing the leukemia caused by hyperplasia of various pthological cells of the non-solid tumor human myeloblast, curing various cancers of cancer cell multiplication of the human solid tumor and diagnosing and detecting the occurrence of the cancer as well as the grade malignancy of occurrence of the cancer, and the short peptide or the nucleotide is used for preparing the drugs as the protease inhibitor, the promoter or the nucleophilic reagent or detecting the detection of the application of the reagent. The technology can solve the problem that the prior cancer drug has serious harm to the normal cells of the human body when inhibiting or killing the cancer cells.

Description

technical field [0001] The invention belongs to the field of biotechnology and medicine, and more specifically relates to a short peptide for inhibiting the growth of solid tumor and leukemia cancer cells and its application. Background technique [0002] Chemotherapy has always been the main part in the process of cancer occurrence and treatment. The existing clinical chemotherapeutic drugs, such as cyclophosphamide, cisplatin, cytarabine, doxorubicin and vincristine, etc., are mainly used to destroy the cell cycle, and RNA, DNA and protein are all of them. target of drugs. In recent years, As 2 o 3 Great progress has been made in the treatment of leukemia. However, this drug and other chemotherapy drugs have their own toxicity. Whether one chemotherapy drug is used alone or several chemotherapy drugs are used in clinical treatment, It has obvious curative effect on cancer, while killing and killing cancer cells, it will also damage the normal cells of the patient. The...

AI Technical Summary

Problems solved by technology

In recent years, As 2 o 3 Great progress has been made in the treatment of leukemia. However, this drug and other chemotherapy drugs have their own toxicity. Whether one chemotherapy drug is used alone or several chemotherapy drugs are used in clinical treatment, It has obvious curative effect on cancer, while killing cancer cells, it will also damage the patient's normal cells

The most common side effect of chemotherapy drugs is the extreme suppression of the patient's bone marrow, causing great pain to the patient, and even death

So far, in addition to early detection of cancer and surgical resection of tumor masses, there is still no specific drug to treat spread tumors and leukemia [Cancer Biology, written by R.J.B Jin, translated by Liu Yixun, Science Press, 2002 ], most of the existing clinically used drugs for cancer treatment are chemical compounds, while the application of short peptides in cancer has not been reported in the literature

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