Detection reagent used for endometriosis uterina

Abstract

The invention relates to a detect reagent for the endometriosis uterine disease, which belongs to the fields of biotechnology and medical inspection. A PR-B mouse anti human monoclonal antibody or / and an NF-Kappa B p5 mouse anti human monoclonal antibody are adopted for being made into the detect reagent and a detect reagent kit. The effect for forecasting the disease palindromia is obtained through detecting the differential expression of relational genes of the endometriosis uterine, such as ERa, PR, PR-B, NF-Kappa B p65 and COX-2 in an internal ectopia palindromia group and a non-palindromia group, and the sensibility, the specificity, the positive predicted value and the negative predicted value are respectively 86.8 percent, 82.1 percent, 0.82 and 0.87. The invention is convenient tocarry out, is favorable to the early diagnosis of the endometriosis uterine disease, and can achieve the purposes for improving and prognosing through the early diagnosis, thereby providing basic reference data for further showing the molecular mechanism on internal ectopia palindromia.

Description

technical field [0001] The invention belongs to the field of biotechnology and medical inspection, and relates to a detection reagent for endometriosis. Background technique [0002] Endometriosis (referred to as endometriosis) is a common disease that seriously affects the quality of life of women of childbearing age. The main clinical manifestations are dysmenorrhea, chronic pelvic pain and infertility. Surgical treatment is currently the first choice for clinical treatment of endometriosis, but clinical practice shows that the recurrence rate is still as high as 40-50% 5 years after surgery, and most patients need a second surgical treatment. Studies have shown that multiple recurrences and surgical treatment can cause reproductive endocrine dysfunction and premature ovarian failure. The recurrence of endometriosis has become a very difficult problem in clinical treatment. However, the reasons for the recurrence of endometriosis are not well understood at present, and t...

AI Technical Summary

Problems solved by technology

Studies have shown that multiple recurrences and surgical treatment can cause reproductive endocrine dysfunction and premature ovarian failure. The recurrence of endometriosis has become a very difficult problem in clinical treatment.

However, the reasons for the recurrence of endometriosis are not well understood at present, and the current rAFS staging system cannot achieve the purpose of predicting recurrence, and the results of relevant epidemiological investigations on high-risk factors for recurrence are also quite controversial , so clinically there is still a lack of a method that can be used to detect endometriosis

Images