Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
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A technology of phosphodiesterase and inhibitors, which can be used in medical preparations containing active ingredients, pharmaceutical formulas, nervous system diseases, etc., and can solve problems such as nerve cell death function and abnormalities
Inactive Publication Date: 2009-08-05
DART NEUROSCIENCE CAYMAN LTD
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Although, thanks to advances in critical care medicine and patient management, patient outcomes after traumatic brain injury (TBI) have improved, there are currently no known treatments that prevent neuronal damage after TBI. death and dysfunction
Although a variety of treatments have been shown to be neuroprotective in preclinical models of TBI, the vast majority of these approaches are not effective in humans
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[0106] The subjects were 103 adult male SD (Sprague-Dawley) rats (Taconic, Gremantown, NY), weighing 275-300 g at the beginning of the experiment. Rats were placed individually in a temperature-controlled animal facility with a light-dark cycle of 12:12 hours, and the animals had free access to food and water. All animal testing protocols are consistent with NIH guidelines, and the animal testing protocol is approved by the Animal Care and Use Committee of Cold Spring Harbor Laboratory
[0107] Motor recovery on a staggered step task
[0108] The staggered step task employed in this study was performed according to the method described by Klint et al. in Journal of Neurotrauma, 21st Annual National Neurotrauma Society Symposium, 20(10):(2003). The staggered step mission consists of an 8' long and 3.5' wide runway connected by a series of 28 elevated steps. The steps are alternately deviated from the center line by 5cm, with a distance of 25cm between every two steps. This a...
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Abstract
The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an animal. The methods comprise a general administration of phosphodiesterase 4 inhibitors and optionally training the animal under conditions sufficient to produce an improvement in performance.
Description
Background technique [0001] It is estimated that 4-5 million Americans (approximately 2% of the elderly and 15% of those over the age of 65) have some form and degree of cognitive deficit. The development of cognitive deficits (abnormalities or loss of cognitive function, the process of acquiring, retaining, and using knowledge) is often associated with diseases or disorders of the central nervous system (CNS), including age-related Associated memory impairment, delirium (sometimes called acute confusional state), dementia (sometimes classified as Alzheimer's dementia or non-Alzheimer's dementia), Alzheimer's disease, Parkinson's disease, Huntington's disease disease (chorea), mental retardation, cerebrovascular disease (e.g., stroke, ischemia), affective disease (e.g., depression), psychiatric disease (e.g., schizophrenia, autism (Karner syndrome), neurological disease (eg, anxiety, obsessive-compulsive disorder), attention deficit disorder (ADD), subdural hematoma, normal p...
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