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Method for refining 1-amyl-3-(4-methyl-1-naphthoyl) indole

A naphthoyl and methyl technology, which is applied in the field of purification and purification of 1-pentyl-3-indole, can solve the problems of high cost, difficult industrial production, low yield and the like, and achieves improved yield, stable properties, and high yield. The effect of high rate and content

Inactive Publication Date: 2011-06-08
NANJING COLLEGE OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Consult relevant bibliographic data, only have the method for by column chromatography for the purification of 1-pentyl-3-(4-methyl-1-naphthoyl) indole, this purification method not only yield is low, and cost is high, Difficult to achieve industrial production

Method used

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  • Method for refining 1-amyl-3-(4-methyl-1-naphthoyl) indole
  • Method for refining 1-amyl-3-(4-methyl-1-naphthoyl) indole

Examples

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Effect test

example 1

[0019] Add 100 g of 75% ethanol aqueous solution to 10 g of crude oily product of 1-pentyl-3-(4-methyl-1-naphthoyl)indole, stir vigorously at 5°C for 0.5 hours, filter, dry in vacuo, and The temperature is 200Pa, the vacuum drying temperature is 20°C, and the drying time is 4 hours to obtain 4.2 g of 1-pentyl-3-(4-methyl-1-naphthoyl)indole refined product, yield: 50%. High performance liquid chromatography analysis, the content is greater than 98.5%.

example 2

[0021] Add 50 g of 85% ethanol aqueous solution to 10 g of crude oil of 1-pentyl-3-(4-methyl-1-naphthoyl)indole, stir vigorously at 10°C for 0.5 hours, filter, dry in vacuo, and The temperature was 180Pa, the vacuum drying temperature was 20°C, and the drying time was 4 hours to obtain 5.1 g of refined 1-pentyl-3-(4-methyl-1-naphthoyl)indole, yield: 51%. High performance liquid chromatography analysis, the content is greater than 98.5%.

example 3

[0023] Add 50 g of 95% ethanol aqueous solution to 10 g of crude oily product of 1-pentyl-3-(4-methyl-1-naphthoyl) indole, stir vigorously at 20°C for 2 hours, filter, dry in vacuo, and The temperature was 160 Pa, the vacuum drying temperature was 20° C., and the drying time was 4 hours to obtain 5.9 g of 1-pentyl-3-(4-methyl-1-naphthoyl)indole refined product, yield: 59%. High performance liquid chromatography analysis, the content is greater than 98.5%.

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Abstract

The invention discloses a method for refining 1-pentyl-3-(4-methyl-1-naphthacyl) indole, relating to a method for refining and purifying the 1-pentyl-3-(4-methyl-1-naphthacyl) indole. The refining method is as below: an oily matter crude of the 1-pentyl-3-(4-methyl-1-naphthacyl) indole, which is obtained through preparation, is added with 75-95 percent of ethanol aqueous solution; the weight ratio of the an oily matter crude of the 1-pentyl-3-(4-methyl-1-naphthacyl) indole and the an oily matter crude of the 1-pentyl-3-(4-methyl-1-naphthacyl) indole is 1 : 1-20; the mixture is subject to violent stirring for 0.5-4 h at a temperature of 5-30 DEG C; filtration and then vacuum drying are carried out, wherein the vacuity is 120-200 Pa, the drying temperature is 2-40 DEG C, and the drying timeis 4-10 h; and then, the finished product of the 1-pentyl-3-(4-methyl-1-naphthacyl) indole is obtained.

Description

technical field [0001] A method for refining 1-pentyl-3-(4-methyl-1-naphthoyl) indole of the present invention relates to a 1-pentyl-3-(4-methyl-1-naphthoyl) Refining and purifying method of indole. Background technique [0002] 1-pentyl-3-(4-methyl-1-naphthoyl)indole, the English name is 1-Pentyl-3-(4-methyl-1-naphthoyl)indole [0003] structural formula [0004] [0005] Indian cannabis (Cannabis sativa L.) and its derivatives have been used for centuries for medicinal and recreational purposes. The main active ingredient in cannabis and cannabis powder has been identified as Δ 9 - THC (Δ 9 -THC). Detailed studies have shown that Δ 9 - The biological action of THC and other members of the cannabinoid family occurs through two G-protein coupled receptors called CB1 and CB2. CB1 receptors are found primarily in the central and peripheral nervous systems, but also in small amounts in some peripheral organs. CB2 receptors are mainly found in lymphoid tissues and cel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/12A61P25/00
Inventor 徐红罗丰茂徐建良孙宏顺周莲凤
Owner NANJING COLLEGE OF CHEM TECH