Artemisia extract containing high content of eupatilin

A technology of extract and extract, which is applied in the field of artemisia extract containing high content of isozanthin, can solve the problems of liver toxicity and achieve the effect of improving drug efficacy

Active Publication Date: 2009-09-02
GL PHARMTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As described in the prior art, dicoumarin sharply reduces the number of platelets even when administered in a small amount, and it is also reported to be hepatotoxic, so it is an ingredient that needs to be administered with great caution even for medical purposes.

Method used

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  • Artemisia extract containing high content of eupatilin
  • Artemisia extract containing high content of eupatilin
  • Artemisia extract containing high content of eupatilin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 20 kg of 2-propanol was added to 2 kg of wormwood (Artemisia princeps Pamp.var. orientalis), and after reflux extraction for about 24 hours, it was filtered with a 400-mesh cloth. Further, 46 kg of 2-propanol was added to the residue, which was filtered with a 400-mesh cloth, and the filtrates were combined and concentrated under reduced pressure while maintaining the temperature around 49° C. to obtain 100 g of a propanol extract of Artemisia praecox. (yield 20:1)

Embodiment 2

[0027] Add 20 kg of 2-propanol to 2 kg of wormwood (Artemisia princeps Pamp.var. orientalis), soak and extract for about 24 hours, then filter it with a 1500-mesh cloth. Add 46 kg of 2-propanol to the residue, filter it with a 400-mesh cloth, combine the filtrates, and concentrate under reduced pressure while maintaining the temperature around 47 to 48° C. to obtain 100 g of a propanol extract of Artemisia. (yield 20:1)

Embodiment 3

[0029] 20 kg of 1-propanol was added to 2 kg of wormwood (Artemisia princeps Pamp.var. orientalis), and after reflux extraction for about 24 hours, it was filtered with a 1500-mesh cloth. Add 46 kg of 2-propanol to the residue, filter it with a 400-mesh cloth, combine the filtrates, and concentrate under reduced pressure while maintaining the temperature around 47 to 48° C. to obtain 100 g of a propanol extract of Artemisia. (yield 20:1)

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PUM

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Abstract

The present invention provides an Artemisia extract containing high content of eupatilin, capable of not only obtaining anti-gastritis Eupatorium heterophyllum with higher content than that in prior art, but also completely removing anticoagulative Artemisia extract. The ethyl carbinol extract of Artemisia having good effect for pathological changes of stomach of the invention is obtained by extracting the Artemisia by using ethyl carbinol, which is characterized by not containing a process of removing dicoumarin in preparation of the extract.

Description

technical field [0001] The invention relates to an Artemisia extract, in particular to an Artemisia extract containing high-content isozanthin obtained by extracting with propanol. Background technique [0002] Artemisia (Artemisia mongolica, A.asiatica, A.princeps var.orientalis, A.argyi, A.montana, etc.) is a perennial medicinal herb belonging to the Compositae family. The clear chemical components include isocoumarin, coumarin, diterpene lactone, etc., and it has also been confirmed that there are eupholzanthin, 4', 5, 7-trihydroxy-3', 6-dimethoxyflavone, etc. Flavonoids. [0003] In the Korean Herbal Pharmacopoeia ( ), the leaves and twigs of the aforementioned Artemisiae are called Artemisiae argyi Herb (Artemisiae argyi Herb). [0004] Among them, eupatilin, a flavonoid component, is known to have an antiallergic effect (Japanese Patent Application Laid-Open No. 59-155314), and its efficacy as a drug for treating gastrointestinal diseases has recently been confirme...

Claims

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Application Information

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IPC IPC(8): A61K36/282A61P1/04A61K31/352
CPCA61K31/352A61K36/282A61K2236/33
Inventor 王埙植朴俊相廉大一吴真燮
Owner GL PHARMTECH
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