Antiinflammatory agent comprising 2-aminophenol or derivative thereof as active ingredient

A technology of aminophenol and active ingredients, applied in the field of anti-inflammatory agents, can solve the problems of unknown anti-inflammatory effects of 2-aminophenol derivatives, and achieve the effect of less side effects

Inactive Publication Date: 2009-09-16
HAYASHIBARA BIOCHEMICAL LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it is not known that 2-aminophenol derivatives have anti-inflammatory effects

Method used

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  • Antiinflammatory agent comprising 2-aminophenol or derivative thereof as active ingredient
  • Antiinflammatory agent comprising 2-aminophenol or derivative thereof as active ingredient
  • Antiinflammatory agent comprising 2-aminophenol or derivative thereof as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] lotion

A Acrylic acid alkyl methacrylic acid copolymer 0.2% by mass

Xanthan gum 0.2% by mass

Pure water 73.0% by mass

B Glycerin 3.0% by mass

Ethanol 17.0% by mass

Sodium hydroxide 0.05% by mass

Pure water 2.5% by mass

Magnesium ascorbyl phosphate 3.0% by mass

Edetate disodium 0.05% by mass

2-aminophenoxazin-3-ketone or 2-aminophenol (and

1.0% by mass

(Sold by Ko Pure Chemical Industry Co., Ltd.)

According to a conventional method, component A is uniformly heated and mixed, cooled, and component B is added to obtain an external preparation for skin.

This product has excellent anti-inflammatory effect and can inhibit the degranulation reaction of basophils or mast cells, so it is also effective in the treatment of atopy. In addition, this product inhibits the synthesis of melanin and enhances the production of collagen. By applying it to the skin, it can suppress the occurrence of de...

Embodiment 2

[0068] Boxed makeup materials

A Polyvinyl alcohol 16.0% by mass

Anhydrous silicic acid 0.5% by mass

Polyethylene glycol 0.5% by mass

Polyoxypropylene methyl glucoside 5.0% by mass

Glycerin 5.0% by mass

Pure water 60.94% by mass

B Ethanol 10.0% by mass

Preservative 0.01% by mass

C disodium edetate 0.05% by mass

2-aminophenoxazin-3-ketone or 2-aminophenol (and

Kopaku Kogyo Co., Ltd.) 1.0% by mass

Pure water 1.0% by mass

Component A was mixed and dissolved by heating at 70°C, and component B was mixed and dissolved. After cooling, component C is uniformly dispersed to obtain a boxed cosmetic material.

This product has excellent anti-inflammatory effect, and has the effect of inhibiting the degranulation reaction of basophils or mast cells, so it is effective in the treatment of atopy. In addition, this product inhibits the synthesis of melanin and enhances the production of collagen. By applying it to the skin, it can suppress the occurrence ...

Embodiment 3

[0069] toothpaste

Prepare toothpaste according to the recipe below.

Insoluble sodium metaphosphate 26.0% by mass

Glycerin 25.0% by mass

Calcium hydrogen phosphate 15.0% by mass

Sodium lauryl sulfate 1.5% by mass

Yellow cyanine gum 1.4% by mass

Fragrance 1.0% by mass

2-aminophenoxazin-3-ketone or 2-aminophenol prepared in Experiment 1 (Wako Pure

Pharmaceutical Co., Ltd.) 0.1% by mass

Saccharin 0.1% by mass

Sodium copper chlorophyllin 1.0% by mass

Water 28.9% by mass

This product has excellent anti-inflammatory effect and has the effect of enhancing collagen production, so it can reduce gingivitis and is suitable for treating or preventing periodontal disease and alveolar pyorrhea.

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Abstract

Disclosed is an anti-inflammatory agent having an excellent effect and having little adverse side-effects. The anti-inflammatory agent comprises 2-aminophenol or a derivative thereof as an active ingredient.

Description

technical field [0001] The present invention relates to an anti-inflammatory agent, in particular to an anti-inflammatory agent containing 2-aminophenol or a derivative thereof as an active ingredient. Background technique [0002] The inflammatory response is one of the important individual responses for the individual to defend against pathogens, and it also causes damage to individual tissues, so excessive inflammatory responses are harmful. Especially for inflammatory reactions in the absence of pathogens such as autoimmune diseases or allergic diseases, it is completely harmful. Therefore, a variety of anti-inflammatory agents have been developed for suppressing inflammatory reactions, such as non-steroidal anti-inflammatory agents such as aspirin, diclofenac, indomethacin, mefenamic acid, prednisolone, hydrocortisone acetate, Steroidal anti-inflammatory agents such as fluprednate, which are used as medicines. [0003] The main symptoms of the inflammatory response ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/136A61K8/41A61K8/49A61K31/5415A61P29/00A61P43/00A61Q19/02
CPCA61K8/49A61K31/136A61K2800/75A61K31/5415A61Q19/02A61Q19/08A61P17/18A61P29/00A61P37/08A61P43/00A61K31/538
Inventor 三宅正树河野惠三佐能吏
Owner HAYASHIBARA BIOCHEMICAL LAB INC
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