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Device for separation and MALDI analysis of an analyte in a sample

An analyte and equipment technology, which is applied in the field of equipment for the separation of analytes in samples and MALDI analysis, and can solve problems such as complex automation requirements for multi-factor analysis

Inactive Publication Date: 2009-09-23
KONINK PHILIPS ELECTRONICS NV
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Problems solved by technology

[0016] Although the SELDI and MALDI methods described above constitute major advances in high-throughput multivariate analysis of biological samples, there are still obstacles to the development of reliable mass spectrometry-based in vitro diagnostic methods that should be overcome
[0017] As noted at the outset, most of today's challenges involve sample handling and preparation, and the rather complex automation requirements for multivariate analysis

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  • Device for separation and MALDI analysis of an analyte in a sample
  • Device for separation and MALDI analysis of an analyte in a sample
  • Device for separation and MALDI analysis of an analyte in a sample

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Embodiment Construction

[0069] As explained above, there is a continuing need for devices that allow separation of biological samples in an easy-to-implement manner, and that enable multi-channel analysis of the separated samples by mass spectrometry.

[0070] The present invention provides devices and methods that address this need. Before describing these aspects of the invention in more detail, some general definitions are provided, which apply throughout the specification of the invention.

[0071] As used in this specification and the appended claims, the singular forms "a" and "an" include the corresponding plural unless the context clearly dictates otherwise. Thus, the term "an analyte" may include more than one analyte, i.e., two, three, four, five, etc. analytes, as well as analyte profiles that together have definitive diagnostic properties. .

[0072] The term "about" in the context of the present invention denotes an interval of accuracy which a person skilled in the art would understan...

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Abstract

The present invention relates to a device for separating at least one analyte in a liquid sample and further analyzing said analyte by laser desorption / ionization (LDI) mass spectrometry. The invention is further concerned with the use of devices for separating at least one analyte in a liquid sample and subsequent determination of the presence and / or amount of said at least one analyte by LDI mass spectrometry. The invention is also concerned with a method for separating at least one analyte in a liquid sample and subsequent determination of the presence and / or amount of said at least one analyte by LDI mass spectrometry.

Description

technical field [0001] The present invention relates to a device for separating at least one analyte in a liquid sample and further analyzing said analyte by laser desorption / ionization (LDI) mass spectrometry. [0002] The invention further relates to the use of a device for separating at least one analyte in a liquid sample and subsequently determining the presence and / or amount of said at least one analyte by means of LDI detection. [0003] The invention also relates to a method for separating at least one analyte in a liquid sample and subsequently determining the presence and / or amount of said at least one analyte by LDI mass spectrometry. Background technique [0004] Bioassays are used to detect the presence and / or amount of an analyte in a biological sample. Typical applications of these bioassays are in vitro diagnostic methods, which have become more common in recent years and are increasingly being used to complement or even replace more traditional diagnostic m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/16
CPCH01J49/0418
Inventor C·里宾O·奥曼
Owner KONINK PHILIPS ELECTRONICS NV
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