Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy

A technology for allergy and composition, applied in the composition for improving or preventing ocular allergy, improving or preventing allergy, treating, controlling, improving or preventing ocular allergy, alleviating field, able to solve the problem of glucocorticoid Suitable for long-term treatment of eye allergy and other problems

Inactive Publication Date: 2009-10-07
BAUSCH & LOMB INC
View PDF28 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, glucocorticoids are not suitable for long-term treatment of ocular allergy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy
  • Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy
  • Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0225] Two mixtures I and II were prepared respectively by mixing the ingredients listed in Table 1. 5 parts by weight of Mixture I were mixed with 20 parts by weight of Mixture II for 15 minutes or more. The pH of the combined mixture was adjusted to 6.2-6.4 using 1N NaOH to obtain the composition of the invention.

[0226] Table 1

[0227] Element

[0228] Carbopol 934P NF

[0229] Alternatively, pure water can be replaced with oils such as cod liver oil, peanut oil, sesame oil, coconut oil, sunflower oil, corn oil or olive oil to prepare oil-based formulations containing compounds of formula IV.

Embodiment 2

[0231] Two mixtures I and II were prepared respectively by mixing the ingredients listed in Table 2. 5 parts by weight of Mixture I were mixed with 20 parts by weight of Mixture II for 15 minutes or more. The pH of the combined mixture was adjusted to 6.2-6.4 using 1 N NaOH to obtain the composition of the invention.

[0232] Table 2

[0233] Element

[0234] Alternatively, pure water can be replaced with oils such as cod liver oil, peanut oil, sesame oil, coconut oil, sunflower oil, corn oil or olive oil to prepare oil-based formulations containing compounds of formula IV.

Embodiment 3

[0236] Two mixtures I and II were prepared respectively by mixing the ingredients listed in Table 3. 5 parts by weight of Mixture I were mixed with 20 parts by weight of Mixture II for 15 minutes or more. The pH of the combined mixture was adjusted to 6.2-6.4 using 1 N NaOH to obtain the composition of the invention.

[0237] table 3

[0238] Element

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A composition for treating, controlling, reducing, ameliorating, or preventing allergy comprises a dissociated glucocorticoid receptor agonist ('DIGRA'), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can comprise an anti-allergic medicament and / or an additional anti-inflammatory agent and can be formulated for topicalapplication, injection, or implantation. The anti-allergic medicament can comprise an antihistamine, a mast-cell stabilizer, a leukotriene inhibitor, an immunomodulator, an anti-IgE agent, or a combination thereof.

Description

Background of the invention [0001] The present invention relates to compositions and methods for treating, controlling, alleviating, ameliorating or preventing allergy. In particular, the present invention relates to compositions comprising isolated glucocorticoid receptor agonists ("DIGRAs") and methods for treating, controlling, alleviating, ameliorating or preventing allergic reactions. More particularly, the present invention relates to compositions and methods for treating, controlling, alleviating, ameliorating or preventing ocular allergy. [0002] An allergy is an overreaction of the body's immune system to foreign substances, called allergens. Inflammatory responses mediated by the immune system are generally divided into four categories: I, II, III and IV. Allergic responses are immediate hypersensitivity reactions of type I reactions in which the individual's body is hypersensitized and develops IgE type antibodies to typical allergens. Mast cells are key compone...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00A61K31/4725A61P37/08A61K45/06A61P27/14
CPCA61K9/0048A61K31/00A61K31/4725A61K45/06A61P27/14A61P29/00A61P37/08A61P5/44
Inventor B·R·勒尔斯T·L·科姆斯托克胡珍泽G·菲利普
Owner BAUSCH & LOMB INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com