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Methods for treating and reducing the incidence of newcastle disease

A Newcastle disease virus, Newcastle disease technology, applied in pharmaceutical formulations, antiviral agents, medical preparations containing active ingredients, etc., can solve the problems of undisclosed treatment, infection and killing of Newcastle disease

Inactive Publication Date: 2009-10-14
THE QUIGLEY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another significant problem is that some highly virulent strains, such as exotic Newcastle disease virus masters, can infect and kill previously vaccinated birds
Although there are some references, such as U.S. Patent Publications 2003 / 0185912 and 2005 / 0147697, which disclose the antiviral properties of compositions comprising turmeric, green tea, ginger, and horseradish, such publications do not disclose the efficacy of treating Newcastle disease. method

Method used

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  • Methods for treating and reducing the incidence of newcastle disease
  • Methods for treating and reducing the incidence of newcastle disease
  • Methods for treating and reducing the incidence of newcastle disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079]

[0080] The formulation can be diluted in a ratio of 1-1300 with water or another suitable diluent to provide a more dilute composition for various applications such as spraying, nebulizing, as an aerosol or as a liquid formulation.

Embodiment 2

[0082] The safety and tolerability study of Composition 1 was carried out in chickens using different doses and routes of administration. The results show that Composition 1 is an effective and suitable liquid additive for poultry feed water, liquid additive for nasal drops or solid additive for poultry feed.

[0083] 132 approximately 7-day-old white Leghorn chickens were divided into 11 groups, given different forms and concentrations of Composition 1 corresponding to Tables 1(a)-1(c), and subsequently exposed to Newcastle disease Virus.

[0084]Tables 1(a)-1(c) summarize the dosage, route and concentration of the composition of the present invention administered to 132 white Legion chickens in the safety and tolerability study.

[0085] Table 1(a)

[0086] Group

chicken number

number of chickens

Route of administration

dose / concentration

1

12

1-12

feed (continuous)

high

2

12

13-24

feed (cont...

Embodiment 3

[0139] The undiluted antiviral composition of Example 1 was prepared, and the diluted composition was tested in VERO E6 cells and in 10-day-old embryonated chicken eggs for antiviral activity against NDV in 10-fold serial dilutions. In addition, placebo was similarly diluted and tested.

[0140] The continuous cell line VERO E6 (CRL-1586) was obtained from the American Type Culture Collection (Rockdale, MD) and was cultured in the presence of 2 mM L-glutamine, 1.5 g / L sodium bicarbonate, 0.1 mM non-essential amino acids, 1.0 mM sodium pyruvate, and 10% fetal bovine serum (InvitrogenCorp [Gibco], Carlsbad, CA) in Minimum Essential Medium (Eagle) at 37°C and 5% CO 2 conditions to reproduce. Cells were grown in T75 flasks (BD Biosciences, Franklin Lakes, NJ) and transferred to 96-well plates and grown to 90% confluency.

[0141] Will 1×10 3 Concentration of B1 / B1 strain of NDV (half tissue culture infectious dose (TCID 50 )) with seven 10-fold serial dilutions (from 1×10 -3 ...

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PUM

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Abstract

A prophylactic treatment for Newcastle disease as well as a treatment of Newcastle disease. The methods comprise the step of administering to a bird, an amount of a composition having a first ingredient obtainable from turmeric; a second ingredient obtainable from green tea; an third ingredient obtainable from ginger; and an acceptable carrier. Compositions in accordance with the invention may be employed for the purpose of reducing the incidence of contracting Newcastle disease or reducing the transmissivity of Newcastle disease.

Description

technical field [0001] The invention relates to a method for treating Newcastle disease or reducing the incidence of Newcastle disease. More particularly, the present invention relates to methods for treating or reducing the incidence and transmissibility of Newcastle disease in poultry. Background technique [0002] Newcastle disease is an acute, febrile and highly contagious disease that affects the respiratory and nervous systems of poultry. Due to its high infectivity and ease of transmission, the disease has been the cause of many epidemics in poultry since 1926. The disease usually has an acute onset and spreads rapidly among susceptible flocks through direct contact with secretions, faeces, respiratory discharges and carcasses (frozen or otherwise) of infected or previously vaccinated poultry. The disease is also spread through contaminated surfaces such as feed, water, equipment or buildings. The disease can cause asymptomatic infection to severe death. In young ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K36/82A61K36/9068A61K36/31A23K1/00A61P31/12
CPCA61K36/31A23K1/1826A61K36/9068A61K36/82A61K36/9066A23K1/182A23K1/14A23K10/30A23K50/70A23K50/75A61P31/12A61K2300/00A61K36/906
Inventor 理查德·罗森布卢姆蒂莫西·卡明斯迈克尔·彼得鲁蒂
Owner THE QUIGLEY