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Method for preparing blending electrospun fiber membrane by adopting membrane protein contained in avian egg shells

A technology of electrospinning fiber and membrane protein, which is applied in the direction of cellulose/protein conjugated artificial filament, electrospinning, fiber treatment, etc. It can solve the problems of low crosslinking degree, low strength and high brittleness of electrospun membrane , to achieve the effects of improved biocompatibility, good biodegradability, and guaranteed strength

Inactive Publication Date: 2009-11-11
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The technical effect of this patented method involves making an electrically spun fibre membranes with strong bacterial resistance while also being easy-to-disassemble for use during medical procedures or treatments.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the performance of biomedical devices made up of synthetic resorbables like polyglycolic acid (PGA), collagen, gelatin, alginate, hyaluronan, calcium hydroxyapatite, magnesium oxide nanoparticles, silica particles, carbon black powders, iron flakes, silver flake, ceramics, metal alloys, plasticizers, lubricants, solvents, water vapor, oxygen gas, nitrogen dioxides, acids, bases, amines, therapeutic agents, antimicrobial substances, growth factors, cells, proteins, nucleus fragments, DNA sequences, carbohydrates, peptidogens, enzyme cofactives, drugs, dyes, pigment dispersion liquids, surfactant solutions, gels, films, foams, sponges, meshes, hydrogel sheets, microfibers, and other applications where electrical conductivity plays an important role.

Method used

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  • Method for preparing blending electrospun fiber membrane by adopting membrane protein contained in avian egg shells
  • Method for preparing blending electrospun fiber membrane by adopting membrane protein contained in avian egg shells
  • Method for preparing blending electrospun fiber membrane by adopting membrane protein contained in avian egg shells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: add 3 milliliters of hexafluoroisopropanols in a beaker, egg shell membrane protein (SEP) 0.075g (50% of the total amount of solute, mass percent, the same), stir, after it dissolves, add poly Propylene carbonate (PPC) 0.075g (50%) was dissolved by stirring to obtain a spinning solution with a concentration of 0.05g / ml. The prepared spinning solution was poured into the spinning solution storage tank of the electrospinning machine, the spinning voltage was adjusted to 15 kV, the spinning receiving distance was 20 cm, and spinning was started. After the spinning solution in the spinning solution storage tank was used up, the electrospun fiber membrane was taken out, and the solvent was removed under vacuum for 6 hours. figure 1 Electron microscopy photographs of egg shell membrane protein-polypropylene carbonate blend electrospun fiber membranes, figure 2 It is an electron microscope photo of NIH3T3 cells cultured on the electrospun fiber membrane for 3 d...

Embodiment 2

[0023] Embodiment 2: change the amount of egg shell membrane protein (SEP) into 0.045g (30%) in embodiment 1, change the amount of polypropylene carbonate (PPC) into 0.105g (70%), solvent uses hexafluoro Isopropanone, the preparation method is the same as in Example 1, and the electrospun fiber membrane has good biocompatibility.

Embodiment 3

[0024] Embodiment 3: change the amount of egg shell membrane protein (SEP) into 0.015g (10%) in embodiment 1, change the amount of polypropylene carbonate (PPC) into 0.135g (90%), and the preparation method is implemented with Example 1, the electrospun fiber membrane has good biocompatibility.

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Abstract

The invention provides a method for preparing blending electrospun fiber membrane by adopting membrane protein contained in avian egg shells, which pertains to the technical field of support materials in tissue engineering. The method is characterized in that one or even more natural or synthetic biodegradable polymers together with soluble membrane protein in egg shells are dissolved in a cosolvent; and electrospun fiber membrane is prepared by elecrospinning process. The method is simple in operation, and the electrospun fiber membrane has good biocompatibility and biodegradability and certain mechanical property. Therefore, the electrospun fiber membrane can be applied to the fields of support materials in tissue engineering, surgical dressings, and the like.

Description

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Claims

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Application Information

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Owner TSINGHUA UNIV
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