Application of high-activity leeches animal extractive in preparing medicament and preparation method of high-activity leeches animal extractive

Abstract

The invention relates to the application of a high-activity leeches animal extractive in preparing medicament and a preparation method of the high-activity leeches animal extractive. The concrete preparation method of the high-activity leeches animal extractive is as follows: the high-activity leeches are hungrily raised in clean water for 5-15 days and then frozen under the temperature of 10-minus 30 DEG C, smashed into homogenate by an organization blender, dried under the temperature below 50 DEG C and crashed into fine powder so as to obtain the high-activity leeches animal extractive. The high-activity leeches animal extractive has simple and available preparation technology, can be prepared into formulations which are acceptable in pharmacology and be used for preparing medicaments with the functions of supplementing vital energy and activating blood and dispersing stagnation and dredging collaterals for preventing blood breaking and eliminating blood stasis, and the high-activity leeches animal extractive can also be applied to analgesic medicaments for promoting blood circulation.

Description

Technical field: [0001] The invention relates to the application and preparation method of highly active leech extracts in the preparation of therapeutic medicines, belonging to the technical field of medicines. Background technique: [0002] Blood stasis disease has always been a serious threat to human health. At present, antiplatelet function inhibitors and anticoagulants are effective methods for antithrombotic therapy. Heparin and warfarin have been used in anticoagulant therapy for decades, but these two drugs still have many limitations. It is reported that 3% of patients will experience heparin-induced thrombocytopenia after using heparin for 5 days. There are many factors for intravascular thrombosis, but the fundamental factors are blood coagulation, platelet adhesion and aggregation. Thrombin plays a vital role in the process of blood coagulation and platelet activation. Therefore, research on thrombin inhibitors has received special attention. The application of...

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Problems solved by technology

[0003] As we all know, the extracts of highly active leeches, whether it is leeches or Hirudo phenanthrene, have been reported in antithrombotic aspects, and leeches are the most representative, because their active ingredient is hirudin, which is mainly used It is used in antithrombotic drugs. At the same time, there are literature and patent reports about its extraction method and its preparation method. However, due to the physical and chemical characteristics of its thrombin inhibitor, its research on extraction methods and preparations needs to be improved. At the same time, the study of fatty acids and amino acids in leech animals by the School of Science of Guangdong Ocean University showed that the identified amino acids and fatty acids in these animals are necessary for the human body, and these amino acids and fatty acids play a role in promoting blood circulation and removing blood stasis. Very important pharmacological effects. At present, in the application of the extract in the preparation of medicines, there is already Maixuekang capsule traditional Chinese medicine preparation, which uses leeches as a single raw material. Due to the relatively limited supply of leeches on the market , so it is of great significance to research and develop the extraction method and application of a new type of highly active leech extract

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